78312-00-2Relevant articles and documents
Mechanistically Guided One Pot Synthesis of Phosphine-Phosphite and Its Implication in Asymmetric Hydrogenation
Sen, Anirban,Kumar, Rohit,Pandey, Swechchha,Vipin Raj,Kumar, Pawan,Vanka, Kumar,Chikkali, Samir H.
supporting information, (2022/01/11)
Although hybrid bidentate ligands are known to yield highly enantioselective products in asymmetric hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an O-nucleophile versus C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72 %). When L1 was treated with [Rh], 31P NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92 %). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1–2 bar H2 pressure, at room temperature. The practical relevance of L1 is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson's disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer.
Experimental and theoretical insights on the adsorption and inhibition mechanism of (2E)-2-(acetylamino)-3-(4-nitrophenyl) prop-2-enoic acid and 4-nitrobenzaldehyde on mild steel corrosion
Arrousse, N.,Chauhan, Dheeraj Singh,Hajjaji, F El,Houari, G Al,Quraishi, M. A.,Rais, Z.,Salim, R.,Taleb, M.,Zarrouk, A.
, (2020/08/24)
Abstract: (2E)-2-(acetylamino)-3-(4-nitrophenyl)prop-2-enoic acid (NPP) was synthesized following a facile chemical method from 4-nitrobenzaldehyde (NB) and thoroughly characterized using spectroscopic techniques. These compounds were applied as novel inhibitors for corrosion of mild steel in 1M HCl using various methods such as absorbance difference, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). The results indicate that these inhibitors show an excellent protection performance and achieve the corrosion inhibition efficiency values of 94percent and 84percent for NPP and NB, respectively. The adsorption of these molecules obeys the El-Awady isotherm model. The surface analysis of mild steel was investigated using scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) methods. Furthermore, quantum chemical calculations were investigated using DFT method at B3LYP/6-31G (d,p) computed by Gaussian 09 showing a good correlation with the experimental results. Graphic abstract: [Figure not available: see fulltext.] Synopsis A novel corrosion inhibitor namely 4-nitrobenzaldehyde derivative NPP was prepared and analyzed for mild steel in 1M HCl. The analysis were conducted by electrochemical, surface supported by DFT based reactivity parameters. NPP functioned by adsorption obeying the El-Awady isotherm and produced a high efficiency of 94percent.
Microwave-assisted synthesis and antimicrobial screening of new imidazole derivatives bearing 4-thiazolidinone nucleus
Desai,Joshi,Rajpara,Vaghani,Satodiya
, p. 1893 - 1908 (2013/07/26)
A new series of compounds 2-((1-(4-(4-arylidene-2-methyl-5-oxo-4,5-dihydro- 1H-imidazol-1-yl)phenyl)ethylidene)hydrazono)thiazolidin-4-ones (4a-o) have been synthesized under conventional and microwave irradiation method. All compounds were characterized by IR, 1H NMR, 13C NMR and mass spectra. Newly synthesized compounds were screened for their antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger and Aspergillus clavatus by bioassays, namely serial broth dilution. The synthesized compounds showed potent antimicrobial activity against tested microorganisms. Compounds 4h, 4j, 4m and 4n were the most potent amongst tested compounds.
