78316-24-2

Basic information

• Product Name: 7,4'-di(methoxymethoxy)flavan-4-one
• Synonyms: 7,4'-di(methoxymethoxy)flavan-4-one
• CAS NO: 78316-24-2
• Molecular Weight: 344.364
• Mol File: 78316-24-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 7,4'-di(methoxymethoxy)flavan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7,4'-di(methoxymethoxy)flavan-4-one(78316-24-2)
• EPA Substance Registry System: 7,4'-di(methoxymethoxy)flavan-4-one(78316-24-2)

Safety Data

• Hazardous Substances Data: 78316-24-2(Hazardous Substances Data)

Upstream product

• 124775-22-0 1-<2-Hydroxy-4-(methoxymethoxy)phenyl>-3-<4-(methoxymethoxy)phenyl>prop-2-en-1-on 
• 78316-23-1 1-(2-hydroxy-4-(methoxymethoxy)phenyl)-3-(4-(methoxymethoxy)phenyl)prop-2-en-1-one 
• 65490-08-6 2-hydroxy-4-(methoxymethoxy)acetophenone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 

Downstream Products

• 69097-97-8 7,4'-dihydroxy-dihydroflavone 
• 124775-22-0 1-<2-Hydroxy-4-(methoxymethoxy)phenyl>-3-<4-(methoxymethoxy)phenyl>prop-2-en-1-on 
• 78316-26-4 4'-hydroxy-7-O-prenylflavanone 
• 78316-28-6 4'-hydroxy-2,2-dimethylpyrano<5,6:6,7>flavanone 
• 78316-27-5 (+/-)-bavachin 

Relevant articles and documents

Synthesis and antitumoractivity of liquiritigenin thiosemicarbazone derivatives

In an attempt to develop potent and selective antitumor agents,a series of liquiritigenin thio-semicarbazone derivatives were designed and synthesized. The cytotoxicities of these compounds were evaluated in vitro against K562,DU-145,SGC-7901,HCT-116 and Hela cell lines. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward K562 and DU-145 cells. From the structureeactivity relationships we may conclude that the introduction of a thiosemicarbazone functional group at the 4-position in the skeleton of liquiritigenin is associated with an increase in cytotoxicity.

New Syntheses of 4',7-Dihydroxy-6,8-di-C-prenylflavanone, Bavachin, Isobavachin and Related Compounds

The titel compounds have been synthesised by nuclear prenylation of 4',7-dihydroxyflavanone(liquiritigenin, III), Cyclodehydrogenation of bavachin and isobavachin with DDQ yields the chromenoflavanones (VIII) and (X) respectively which on dehydrogenation