78346-78-8Relevant articles and documents
Optimization of subsite binding to the β5 subunit of the human 20S proteasome using vinyl sulfones and 2-keto-1,3,4-oxadiazoles: Syntheses and cellular properties of potent, selective proteasome inhibitors
Rydzewski, Robert M.,Burrill, Leland,Mendonca, Rohan,Palmer, James T.,Rice, Mark,Tahilramani, Ram,Bass, Kathryn E.,Leung, Ling,Gjerstad, Erik,Janc, James W.,Pan, Lin
, p. 2953 - 2968 (2007/10/03)
Beginning with the peptide sequence Cbz-Ile-Glu(OtBu)-Ala-Leu found in PSI (3), a series of vinyl sulfones (VS) were synthesized for evaluation as inhibitors of the chymotrypsin-like activity of the 20S proteasome. Variations at the key P3 position confir
Total Synthesis of Thymosin β4, 3. Conventional Synthesis of the Fragment of Thymosin β4
Link, Peter,Voelter, Wolfgang
, p. 1000 - 1008 (2007/10/02)
As part of our total synthesis of thymosin β4, an optimized synthesis of the C-terminal part of thymosin β4 is described.Side chain functional residues of the tridecapeptide are masked by tert-butyl and the α-amino-acids residues are protected by the Z groups.The fully protected peptide derivative was obtained by WSCI/HOBt coupling of three fragments representing the segments , and . Key words: Thymosin β4; fragment ; peptide; solution synthesis; thymosins.