784105-33-5 Usage
Description
alpha-aMine-oMega-propionic acid triethylene glycol, also known as Amino-PEG3-acid, is a PEG reagent that contains an amino (NH2) group and a terminal carboxylic acid group. The hydrophilic PEG unit enhances hydrophilicity, while the NH2 amine group is reactive with carboxylic acids in the presence of coupling reagents like EDC or directly with NHS esters, forming a stable amide bond.
Uses
Used in Pharmaceutical Industry:
alpha-aMine-oMega-propionic acid triethylene glycol is used as a building block for the preparation of MUC1-glycopeptide-BSA conjugate vaccines bearing (deoxy)(fluoro)-Thomsen-Friedenreich antigen. This application is significant for the development of vaccines targeting specific antigens, potentially improving the effectiveness of immunotherapies.
Used in Bioconjugation:
In the field of bioconjugation, alpha-aMine-oMega-propionic acid triethylene glycol serves as a versatile PEG reagent that can be used to form stable amide bonds with carboxylic acid-containing molecules. This property is valuable for creating bioconjugates with improved solubility, stability, and bioavailability, which are essential for various biomedical applications, including drug delivery and molecular imaging.
Check Digit Verification of cas no
The CAS Registry Mumber 784105-33-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,8,4,1,0 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 784105-33:
(8*7)+(7*8)+(6*4)+(5*1)+(4*0)+(3*5)+(2*3)+(1*3)=165
165 % 10 = 5
So 784105-33-5 is a valid CAS Registry Number.
784105-33-5Relevant articles and documents
Preparation method of amino polyethylene glycol propionic acid
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, (2019/01/14)
The invention relates to the field of organic synthesis, in particular to a preparation method of amino polyethylene glycol propionic acid. The preparation method comprises the steps that catalytic hydrogenation is carried out on dibenzyl amino polyethylene glycol tert-butyl propionate shown in formula I-2 to obtain amino polyethylene glycol tert-butyl propionate shown in formula I-3; (2) the amino polyethylene glycol tert-butyl propionate shown in formula I-3 is hydrolyzed under the acidic condition to obtain amino polyethylene glycol propionic acid shown in formula I. The preparation methodof the amino polyethylene glycol propionic acid has the advantages that the defects in the prior art that the yield is low, the dangerousness is high, and the enlargement of production is difficult are overcome, the reaction conditions are mild, the operation is simple, an intermediate does not to be purified, the next reaction can be directly carried out, the whole yield reaches up to 87-92%, thepurity of end products reaches up to 97-99.5%, and a safe and efficient synthetic route is provided for the preparation of amino polyethylene glycol propionic acid.