78468-34-5

Basic information

• Product Name: 2-AMINO-4-NITROBENZENEMETHANOL
• Synonyms: 2-amino-4-nitro-benzylalcoho;2-AMINO-4-NITROBENZYL ALCOHOL;2-AMINO-4-NITROBENZENEMETHANOL;(2-amino-4-nitrophenyl)methanol;(2-Amino-4-nitrophenyl)methanol, 2-(Hydroxymethyl)-5-nitroaniline
• CAS NO: 78468-34-5
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.15
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 78468-34-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 178-180 °C
• Boiling Point: 424.1°C at 760 mmHg
• Flash Point: 210.3°C
• Appearance: /
• Density: 1.432g/cm³
• Vapor Pressure: 6.01E-08mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 13.46±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-4-NITROBENZENEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-4-NITROBENZENEMETHANOL(78468-34-5)
• EPA Substance Registry System: 2-AMINO-4-NITROBENZENEMETHANOL(78468-34-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 78468-34-5(Hazardous Substances Data)

Usage

General Description

2-Amino-4-nitrobenzenemethanol is a chemical compound with the molecular formula C7H8N2O3. It is a white to light yellow solid that is often used as an intermediate in the synthesis of pharmaceuticals and dyes. 2-AMINO-4-NITROBENZENEMETHANOL is also known for its antibacterial and antifungal properties, making it a valuable component in the development of new drugs to combat infectious diseases. As a nitrobenzene derivative, 2-amino-4-nitrobenzenemethanol is classified as a hazardous substance and should be handled with caution to prevent potential health risks.

InChI:InChI=1/C7H8N2O3/c8-7-3-6(9(11)12)2-1-5(7)4-10/h1-3,10H,4,8H2

Upstream product

• 619-17-0 4-Nitroanthranilic acid 
• 3558-19-8 methyl 2-amino-4-nitrobenzoate 
• 651733-07-2 2-acetamido-4-nitrobenzyl bromide 
• 2879-79-0 N-(2-methyl-5-nitrophenyl)acetamide 
• 651733-13-0 2-acetamido-4-nitrobenzyl alcohol 
• 121-14-2 2,4-dinitrotoluene 

Downstream Products

• 1453169-02-2 7-nitro-2-phenylquinazoline 
• 571186-90-8 C₂₉H₃₁N₇O₂ 
• 1613505-52-4 C₂₄H₁₈N₂O₅S 
• 109466-84-4 4-nitro-2-aminobenzaldehyde 
• 1042972-63-3 7-nitro-1H-benzo[d][1,3]oxazin-2-(4H)-one 
• 1172621-16-7 methyl 2-(hydroxymethyl)-5-nitrophenylcarbamate 
• 262863-79-6 (Z)-3-(2-Azido-4-nitro-phenyl)-2-[(2-chloro-pyridine-3-carbonyl)-amino]-acrylic acid methyl ester 

Relevant articles and documents

Selective sodium channel regulator as well as preparation and application thereof

The invention provides a compound serving as a selective sodium channel regulator and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the selective sodium channel regulator. The compounds exhibit excellent activity as a regulator of sodium channels.

ARYL AMIDE KINASE INHIBITORS

The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Synthesis of quinolinomorphinan derivatives as highly selective δ opioid receptor ligands

We have reported previously the novel δ opioid agonist KNT-127 which showed high affinity and selectivity for the δ receptor. Moreover, the analgesic effect of subcutaneously administered KNT-127 was more potent than that of a prototypical δ agonist (-)-TAN-67 in the acetic acid writhing test. This study of the structure-activity relationship of KNT-127 derivatives focused on the introduction of substituents onto the 5′-, 6′-, 7′- or 8′-position of the quinoline ring and revealed that many derivatives with 5′- or 8′-substituents showed high affinities and selectivities for the δ receptor. Especially, SYK-153 with an 8′-OH group showed the highest affinity and the most balanced and highest selectivity for the δ receptor among the synthesized compounds.