78491-02-8

Basic information

• Product Name: Diazolidinyl Urea
• Synonyms: Diazolidinyl Urea (diazonium imidazolidinyl urea);N-(Hydroxymethyl)-N-(1,3-dihydroxymethyl-2,5-dioxo-4-imidazolidinyl)-N’-(hydroxymethyl)urea;roxymethyl)urea;urea,n-(1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-n,n’-bis(hydroxymet;urea,n-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-n,n’-bis(hydroxymet;Urea,N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N’-bis(hydroxymethyl)-;DIAZOLIDINYL UREA;1-[1,3-bis(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-1,3-bis(hydroxymethyl)urea
• CAS NO: 78491-02-8
• Molecular Formula: C₈H₁₄N₄O₇
• Molecular Weight: 278.22
• EINECS: 278-928-2
• Product Categories: Antibiotics for Research and Experimental Use;Biochemistry;Others (Antibiotics for Research and Experimental Use);Azo/Diazo Compounds;Nitrogen Compounds;Organic Building Blocks;Azo/Diazo Compounds;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 78491-02-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 421.04°C (rough estimate)
• Appearance: white powder
• Density: 1.4734 (rough estimate)
• Vapor Pressure: 0Pa at 20℃
• Refractive Index: 1.6590 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Water (Slightly)
• PKA: 11.22±0.46(Predicted)
• Water Solubility: 1000g/L at 20℃
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 14,3000
• CAS DataBase Reference: Diazolidinyl Urea(CAS DataBase Reference)
• NIST Chemistry Reference: Diazolidinyl Urea(78491-02-8)
• EPA Substance Registry System: Diazolidinyl Urea(78491-02-8)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 2
• RTECS: YS2717000
• Hazardous Substances Data: 78491-02-8(Hazardous Substances Data)

Usage

Description

Diazolidinyl urea, a formaldehyde re1easer, is mainly contained in cosmetics and toiletries, and can be found in barrier creams.

Chemical Properties

white powder

Uses

Different sources of media describe the Uses of 78491-02-8 differently. You can refer to the following data:
1. Antimicrobial preservative in cosmetics and toiletries.
2. diazolidinyl urea is an antiseptic and deodorizer. It is also a broadspectrum preservative against bacteria and fungi. generally, it is used in concentrations of 0.03 to 0.3 percent. It has been found that diazolidinyl urea is a stronger sensitizer than imidazolidinyl urea for people sensitive or allergic to formaldehyde.
3. 2,5-Diazolidinylurea is a preservative used in cosmetic creams, lotions, shampoos, hair gels, etc.

Flammability and Explosibility

Nonflammable

Contact allergens

Diazolidinyl urea, a formaldehyde releaser, is contained mainly in cosmetics and toiletries and can be found in barrier creams.

InChI:InChI=1/C4H10N4O/c5-4(9)7-8-2-1-6-3-8/h6H,1-3H2,(H3,5,7,9)

Synthetic route

diazolidinyl urea (78491-02-8) → formaldehyd (50-00-0)

Conditions	Yield
In aq. phosphate buffer; water-d2; acetonitrile at 37℃; for 0.5h; pH=7.4; Sealed tube;

Downstream Products

• 50-00-0 formaldehyd 

Relevant articles and documents

Emollient

The present invention is a compound containing a cactus extract, which moistens the skin when the skin is exposed to radiation, such as during radiation treatment, sunburn or other types of burns.

Mild, rinse-off antimicrobial liquid cleansing compositions containing salicyclic acid

The present invention relates to a rinse-off antimicrobial cleansing composition comprising from about 0.1% to about 5.0%, by weight of the cleansing composition, of an antimicrobial active; from about 6% to about 16%, by weight of the cleansing composition, of an anionic surfactant, wherein at least about 67% of the anionic surfactant is selected from the group consisting of Class A surfactants, Class C surfactants, and mixtures thereof, wherein the ratio of Class A surfactant to Class C is from about 100:0 to about 1.5:1; from about 2% to about 4%, by weight of the cleansing composition, of a proton donating agent having a Biological Activity Index, Z, of greater than about 0.75, wherein the proton donating agent is such that the composition is essentially free of C4-C20 alkyl fatty acid, and wherein from about 0.15% to about 2%, by weight of the cleansing composition, of the proton donating agent is salicylic acid; a mildness enhancing agent selected from the group consisting of from about 20% to about 70%, by weight of the anionic surfactant, of a mildness enhancing cosurfactant; from about 0.1% to about 1.0%, by weight of the cleansing composition, of a mildness enhancing polymer; and mixtures thereof, and from about 35% to about 95.75%, by weight of the cleansing composition, of water; wherein the composition is adjusted to a pH of greater than about 3 and less than about 6. The invention also encompasses methods for cleansing skin and providing residual effectiveness versus Gram negative bacteria using these products.

Method and composition for preserving antigens and process for utilizing cytological material produced by same

A method and composition for fixing and stabilizing tissues, cells, and cell components such that the antigenic sites are preserved for a useful period of time is provided. The fixative employs a formaldehyde donor that is non-toxic, non-flammable, and that stabilizes the cell with minimal damage to and alteration of the cell morphology. The cell antigenic sites are left intact so that studies with monoclonal antibodies may be conducted. Vaccines and related immunotherapeutic methods utilizing antigens stabilized by the fixative of the present invention are also provided. The invention also discloses a method for developing a positive control for test reagents and for test instrumentation.