78495-65-5

Basic information

• Product Name: 4-Fluoro-3-methoxyphenylacetic acid
• Synonyms: 2-(4-fluoro-3-Methoxyphenyl)acetic acid;2-(2-Fluoro-3,4-diMethoxyphenyl)acetic acid
• CAS NO: 78495-65-5
• Molecular Formula: C₁₀H₁₁FO₄
• Molecular Weight: 184.1644
• Product Categories: Fluorine series
• Mol File: 78495-65-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 103-107℃
• Boiling Point: 317.1 °C at 760 mmHg
• Flash Point: 145.6 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 0.000165mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Fluoro-3-methoxyphenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-3-methoxyphenylacetic acid(78495-65-5)
• EPA Substance Registry System: 4-Fluoro-3-methoxyphenylacetic acid(78495-65-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 78495-65-5(Hazardous Substances Data)

Usage

General Description

4-Fluoro-3-methoxyphenylacetic acid is a chemical compound with the molecular formula C9H9FO3. It is a derivative of phenylacetic acid with a fluorine atom at the 4-position and a methoxy group at the 3-position on the phenyl ring. 4-Fluoro-3-methoxyphenylacetic acid is used in organic synthesis and medicinal chemistry as a building block for the preparation of pharmaceuticals and other biologically active molecules. It has potential applications in the development of new drugs for various therapeutic uses due to its structural properties and reactivity. However, it is important to handle and use this compound with caution as it may pose potential health hazards if not properly managed.

InChI:InChI=1/C9H9FO3/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4H,5H2,1H3,(H,11,12)

Upstream product

• 78495-64-4 (2-fluoro-3,4-dimethoxyphenyl)acetonitrile 
• 7537-08-8 2-fluoro-3,4-dimethoxyphenylacetonitrile 

Downstream Products

• 103346-76-5 ethyl hydrogen α-<2-(2-fluoro-3,4-dimethoxyphenyl)ethyl>malonate 
• 107088-99-3 Benzyl-[8-fluoro-6,7-dimethoxy-3,4-dihydro-1H-naphthalen-(2E)-ylidene]-amine 
• 103346-74-3 diethyl α-<2-(2-fluoro-3,4-dimethoxyphenyl)ethyl>malonate 
• 103346-72-1 2-(2-fluoro-3,4-dimethoxyphenyl)ethyl tosylate 
• 103346-87-8 (5-Fluoro-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid benzyl ester 
• 104422-00-6 N-allyl-6-fluoro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol hydrobromide 
• 104421-99-0 N-<2-(4-methoxyphenyl)-2-hydroxyethyl>-2-(3,4-dimethoxy-2-fluorophenyl)acetamide 
• 104421-92-3 3-Allyl-6-fluoro-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 95413-95-9 N-<2-hydroxy-2-(4-methoxyphenyl)>-2-(3,4-dimethoxy-2-fluorophenyl)ethylamine 
• 72912-25-5 6-Fluoro-7,8-dimethoxy-1-(4-methoxy-phenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 103346-89-0 (2-fluoro-3,4-dimethoxyphenyl)acetyl chloride 
• 103346-70-9 2-(2-fluoro-3,4-dimethoxyphenyl)ethanol 

Relevant articles and documents

Dopamine Agonists Related to 3-Allyl-6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol. 6-Position Modifications

The N-allyl derivative (SK and F 85174) of 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7,8-diol (SK and F 82526) retains the DA-1 agonist potency of the latter compound but unlike the parent also shows substantial DA-2 agonist activity.In a previous study of N-substituted benzazepines these combined agonist effects were shown to be uniquely associated with the N-allyl group.A continuation of this research has examined dependency of combined DA-2/DA-1 agonist activities on 6=position modification with the specific objective of developing an agonist with maximum effectiveness and potency at the DA-2 receptor subtype.DA-2 agonist activity was measured in a rabbit ear artery assay, and DA-1 agonist activity was determined in an adenylate cyclase assay.Replacing chloro with bromo retains the activity pattern and the potency of the chloro compound: replacement with a hydrogen causes a decrease of both DA-1 and DA-2 receptor activating potency.Introduction of a 6-methyl group causes loss of DA-2 agonist activity and reduction in DA-1 agonist potency.Substitution with a 6-fluoro provides the best balance of DA-2 and DA-1 agonist activities; this compound was moderately in both assays.

6-PHENYL THIO- AND 6-CYCLOHEXYL THIO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES

Mercapto substituted-2,3,4,5-tetrahydro-1H-3-benzazepines having dopamine receptor blocking activity are prepared from o-quinones or via standard preparative procedures.