78644-76-5

Basic information

• Product Name: 2-Pyridinamine, N-(3-methoxyphenyl)-
• CAS NO: 78644-76-5
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.24
• Mol File: 78644-76-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-Pyridinamine, N-(3-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinamine, N-(3-methoxyphenyl)-(78644-76-5)
• EPA Substance Registry System: 2-Pyridinamine, N-(3-methoxyphenyl)-(78644-76-5)

Safety Data

• Hazardous Substances Data: 78644-76-5(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 536-90-3 m-Anisidine 
• 504-29-0 2-aminopyridine 
• 10365-98-7 3-methoxyphenylboronic acid 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 766-85-8 3-methoxy-1-iodobenzene 
• 5029-67-4 2-iodopyridine 
• 109-09-1 2-chloropyridine 

Downstream Products

• 99261-88-8 7-methoxybenzo[4,5]imidazo[1,2-a]pyridine 
• 1312175-22-6 9-methoxypyrido[1,2-a]benzimidazole 
• 1416353-62-2 7-methoxy-1-phenyl-9-(pyridin-2-yl)-9H-carbazole 
• 1416353-63-3 2-methoxy-1-phenyl-9-(pyridin-2-yl)-9H-carbazole 
• 1256380-89-8 C₂₆H₂₀N₂O 

Relevant articles and documents

Copper anchored on phosphorus g-C3N4as a highly efficient photocatalyst for the synthesis ofN-arylpyridin-2-amines

A heterogeneous photocatalyst based on copper modified phosphorus doped g-C3N4(Cu/P-CN) has been prepared and characterized. This recyclable catalyst exhibited high photocatalytic activity for the synthesis ofN-arylpyridin-2-amine derivatives by the reaction of 2-aminopyridine and aryl boronic acid at room temperature under the irradiation of blue light. Importantly, the range of substrates for this coupling reaction has been expanded to include aryl boronic acids with strong electron-withdrawing groups as viable raw materials. In addition, this heterogeneous catalyst can be used at least 6 times while maintaining its catalytic activity.

Dialkylterphenyl Phosphine-Based Palladium Precatalysts for Efficient Aryl Amination of N-Nucleophiles

A series of 2-aminobiphenyl palladacycles supported by dialkylterphenyl phosphines, PR2Ar′ (R=Me, Et, iPr, Cyp (cyclopentyl), Ar′=ArDipp2, ArXyl2f, Dipp (2,6-C6H3-(2,6-C6H3-(CHMe2)2)2), Xyl=xylyl) have been prepared and structurally characterized. Neutral palladacycles were obtained with less bulky terphenyl phosphines (i.e., Me and Et substituents) whereas the largest phosphines provided cationic palladacycles in which the phosphines adopted a bidentate hemilabile k1-P,η1-Carene coordination mode. The influence of the ligand structure on the catalytic performance of these Pd precatalysts was evaluated in aryl amination reactions. Cationic complexes bearing the phosphines PiPr2ArXyl2 and PCyp2ArXyl2 were the most active of the series. These precatalysts have demonstrated a high versatility and efficiency in the coupling of a variety of nitrogen nucleophiles, including secondary amines, alkyl amines, anilines, and indoles, with electronically deactivated and ortho-substituted aryl chlorides at low catalyst loadings (0.25–0.75 mol % Pd) and without excess ligand.

Direct C-H alkylation and indole formation of anilines with diazo compounds under rhodium catalysis

The rhodium(iii)-catalyzed direct functionalization of aniline C-H bonds with α-diazo compounds is described. These transformations provide a facile construction of ortho-alkylated anilines with diazo malonates or highly substituted indoles with diazo acetoacetates.