78664-72-9

Basic information

• Product Name: 2-Piperidinecarboxylic acid, 6-oxo-, pentafluorophenyl ester, (S)-
• CAS NO: 78664-72-9
• Molecular Formula: C12H8F5NO3
• Molecular Weight: 309.192
• Mol File: 78664-72-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Piperidinecarboxylic acid, 6-oxo-, pentafluorophenyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinecarboxylic acid, 6-oxo-, pentafluorophenyl ester, (S)-(78664-72-9)
• EPA Substance Registry System: 2-Piperidinecarboxylic acid, 6-oxo-, pentafluorophenyl ester, (S)-(78664-72-9)

Safety Data

• Hazardous Substances Data: 78664-72-9(Hazardous Substances Data)

Upstream product

• 24325-14-2 (2S)-2-[(phenylmethoxy)carbonyl]aminoadipic acid 
• 102922-72-5 (S)-2-(((benzyloxy)carbonyl)amino)-6-hydroxyhexanoic acid 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 1118-90-7 L-homoglutamic acid 
• 6033-32-5 (S)-2-amino-6-hydroxyhexanoic acid 
• 771-61-9 2,3,4,5,6-pentafluorophenol 
• 34622-39-4 (2S)-6-oxopipecolic acid 
• 83793-27-5 L-2-amino-5-<(benzyloxycarbonyl)carbamoyl>pentanoic acid 

Downstream Products

• 1287270-44-3 C₂₈H₃₈N₆O₄ 
• 1287270-42-1 C₂₇H₃₆N₆O₄ 
• 1287270-40-9 C₂₇H₃₆N₆O₄ 
• 1287270-52-3 C₃₄H₄₄N₆O₄ 
• 78664-73-0 L-pyro-2-aminoadipyl-L-leucyl-L-prolinamide 

Relevant articles and documents

Synthesis of Thyrotropin-Releasing Hormone Analogues. 2. Tripeptides Structurally Greatly Differing from TRH with High Central Nervous System Activity

A new series of thyrotropin-releasing hormone (TRH) analogues, obtained by further modifications of our most potent central nervous system (CNS) stimulating neutral tripeptides at both termini, were synthesized by the pentafluorophenyl ester method and tested for CNS and thyrotropin (TSH) releasing activity.Replacement of pyroglutamic acid by pyro-2-aminoadipic acid, 2-oxoimidazolidine-4-carboxylic acid or γ-butyrolactone-γ-carboxylic acid and that of proline by pipecolic acid, thiazolidine-4-carboxylic acid, or homoproline in 2>- and 2>TRH led to tripeptides structurally widely different from TRH.In spite of this fact, 7 of the 17 analogues (1, 2, 8-10, 16, and 17) have stronger anticataleptic effect than TRH, with negligible or no hormonal potency.The highest CNS activity was achieved when pyroglutamic acid was replaced by pyro-2-aminoadipic acid at the N-terminus .A novel synthesis of L-2-aminoadipic acid suitable for large-scale preparation is also described.