78681-09-1 Usage
Description
(R)-(+)-N-[1-(1-NAPHTHYL)ETHYL]SUCCINAMIC ACID, also known as (R)-1-phenylethylsuccinamic acid, is a chiral chemical compound that is commonly used in the pharmaceutical industry. It is a white to off-white crystalline powder that is soluble in water and ethanol. (R)-(+)-N-[1-(1-NAPHTHYL)ETHYL]SUCCINAMIC ACID is primarily used as a resolving agent for chiral compounds and as a building block in the synthesis of various pharmaceuticals and biologically active molecules. Its (R)-enantiomer possesses specific pharmacological and therapeutic properties, making it a valuable component in drug development and synthesis. Additionally, it is also used as a reagent in organic synthesis and as a chiral ligand in asymmetric catalysis. Overall, (R)-(+)-N-[1-(1-NAPHTHYL)ETHYL]SUCCINAMIC ACID is an important chemical compound with various applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
(R)-(+)-N-[1-(1-NAPHTHYL)ETHYL]SUCCINAMIC ACID is used as a resolving agent for chiral compounds, which is crucial in the development and synthesis of pharmaceuticals with desired properties and reduced side effects.
Used in Drug Development:
(R)-(+)-N-[1-(1-NAPHTHYL)ETHYL]SUCCINAMIC ACID is used as a building block in the synthesis of various pharmaceuticals and biologically active molecules, contributing to the creation of new drugs with specific therapeutic properties.
Used in Organic Synthesis:
(R)-(+)-N-[1-(1-NAPHTHYL)ETHYL]SUCCINAMIC ACID is used as a reagent in organic synthesis, facilitating the production of a wide range of chemical compounds.
Used in Asymmetric Catalysis:
(R)-(+)-N-[1-(1-NAPHTHYL)ETHYL]SUCCINAMIC ACID is used as a chiral ligand in asymmetric catalysis, which is essential for the selective synthesis of enantiomerically pure compounds with specific biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 78681-09-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,6,8 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 78681-09:
(7*7)+(6*8)+(5*6)+(4*8)+(3*1)+(2*0)+(1*9)=171
171 % 10 = 1
So 78681-09-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H17NO3/c1-11(17-15(18)9-10-16(19)20)13-8-4-6-12-5-2-3-7-14(12)13/h2-8,11H,9-10H2,1H3,(H,17,18)(H,19,20)/t11-/m1/s1
78681-09-1Relevant articles and documents
Chemistry at Rigid Surfaces, 6. - Photochemically Induced Reactions with Surface-bound Sensitizers
Horner, Leopold,Klaus, Joachim
, p. 792 - 810 (2007/10/02)
AerosilR reacts with 3-triethoxysilylpropylamine to give Aminoaerosil (1) which can be converted into aerosils 2a - f by means of sensitizers containing carboxyl groups.The density of the functional groups on the surface which was determined by several methods clearly effects the reaction.On irradiation in 2-propanol, acetone was produced as well as the surface-bound pinacol, e. g. 4, which could be reoxidized by lead tetraacetate to give 2b.Hydrodimerization on the surface of 2b proceeds three times more slowly than with the homogeneous analogues.The photoreduction of 2b with a minor surface density, gave - in addition to 4 - the carbinol 8 and the mixed pinacol 9. - The aerosil with surface-bound p-acetylbenzoic acid (modified aerosil 2b) is investigated in comparison to the homogeneous system: experiments were made in (S)-p-menth-3-yl lactate and (R,S)-p-menth-3-yl-lactate.In both cases the surface-bound pinacol 4 was formed, and in the latter case a decrease in the optical activity of the lactate was observed. - With surface-bound sensitizers the following photochemically induced reactions were studied: a) the photosensitized addition of 2-propanol to maleic acid and diethyl maleate to give terebinic acid (12a) or its methyl ester, respectively; b) the sensitized cis/trans isomerization of maleic acid or diethyl fumarate; c) the sensitized cis/trans isomerization of 1,2-diphenylcyclopropane; d) the sensitized autoxidation of 2,5-dimethylfuran. - All four reactions, although slower, yield the same products as in the analogous homogeneous system.In reaction b), c), and d) the efficiency factor WF (ratio of reaction rates in homo- and heterogeneous system) and the reutilization factor SF (ratio of co nversions after a given time in the first and second experiment) was determined for the heterogeneous sensitizer.
