78708-35-7Relevant articles and documents
The basal SAR of a novel insulin receptor activator
Wood Jr., Harold B.,Black, Regina,Salituro, Gino,Szalkowski, Deborah,Li, Zhihua,Zhang, Yan,Moller, David E.,Zhang, Bei,Jones, A. Brian
, p. 1189 - 1192 (2000)
The synthesis and SAR of analogues prepared from novel insulin receptor activator 1 are described. Changes to the dihydroxyquinone core were not tolerated while functionalization of the two indoles contained in 1 resulted in little effect upon activation of the insulin receptor. (C) 2000 Elsevier Science Ltd. All rights reserved.
Methyl scanning: Total synthesis of demethylasterriquinone B1 and derivatives for identification of sites of interaction with and isolation of its receptor(s)
Pirrung, Michael C.,Liu, Yufa,Deng, Liu,Halstead, Diana K.,Li, Zhitao,May, John F.,Wedel, Michael,Austin, Darrell A.,Webster, Nicholas J. G.
, p. 4609 - 4624 (2007/10/03)
The principle of methyl scanning is proposed for determination of the sites of interaction between biologically active small molecules and their macromolecular target(s). It involves the systematic preparation of a family of methylated derivatives of a co