78739-00-1

Basic information

• Product Name: Fulvicin
• Synonyms: NSC 41728;Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R-trans)-
• CAS NO: 78739-00-1
• Molecular Formula: C₁₇H₁₇ClO₆
• Molecular Weight: 352.76628
• EINECS: 204-767-4
• Mol File: 78739-00-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 217-224℃
• Boiling Point: 527.9°C at 760 mmHg
• Flash Point: 205.9°C
• Appearance: /
• Density: 1.35g/cm³
• Vapor Pressure: 3.11E-11mmHg at 25°C
• Refractive Index: 1.565
• Water Solubility: practically insoluble
• CAS DataBase Reference: Fulvicin(CAS DataBase Reference)
• NIST Chemistry Reference: Fulvicin(78739-00-1)
• EPA Substance Registry System: Fulvicin(78739-00-1)

Safety Data

• Hazard Codes: T:Toxic
• Statements: R60:; R61:; R40:; R43:
• Safety Statements: S53:; S22:; S36/37/39:; S45:
• Hazardous Substances Data: 78739-00-1(Hazardous Substances Data)

Usage

Description

Fulvicin, also known as griseofulvin, is an oral antifungal medication used to treat various fungal infections such as ringworm, athlete's foot, and jock itch. It is a fungistatic agent that prevents the growth and reproduction of fungi rather than directly killing them. Fulvicin is particularly effective against dermatophyte infections and is typically prescribed as a course of treatment for several weeks or months, depending on the severity of the infection.

Uses

Used in Pharmaceutical Industry:
Fulvicin is used as an antifungal medication for treating various fungal infections, including ringworm, athlete's foot, and jock itch. It works by stopping the growth of fungi, making it particularly effective against dermatophyte infections.
Used in Healthcare:
Fulvicin is used as a treatment under the guidance of a healthcare professional to ensure its effectiveness and monitor for potential side effects, which may include headache, nausea, vomiting, diarrhea, and allergic reactions. Regular monitoring by a healthcare provider is important to ensure the medication is effective and not causing any adverse effects.

InChI:InChI=1/C17H19ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h7-8,12H,5-6H2,1-4H3/t8-,12?,17+/m1/s1

Upstream product

• 7776-77-4 (+/-)-dehydrogriseofulvin 
• 3573-90-8 (-)-dehydrogriseofulvin 
• 132692-41-2 7-chloro-4,6-dimethoxy-2-<5-methoxy-1-(methylthio)-3-oxohexylidene>-3(2H)-benzofuranone 
• 67-56-1 methanol 
• 26881-62-9 dl-2'-demethoxy-2'-(methylthio)griseofulvin 
• 132692-40-1 5-Methoxy-1,1-bis-methylsulfanyl-hex-1-en-3-one 
• 126-07-8 d,l-epigriseofulvin 
• 129529-56-2 (Z)-7-chloro-4,6-dimethoxy-2-(1-propylidene)-3(2H)-benzofuranone 
• 3261-06-1 7-chloro-4,6-dimethoxy-2,3-dihydrobenzofuran-3-one 
• 67844-80-8 (Z)-7-chloro-2-ethylidene-4,6-dimethoxy-3(2H)-benzofuranone 
• 130423-15-3 C₁₇H₁₇ClO₆S 
• 61539-61-5 1,1-dimethoxy-3-trimethylsilyloxy-1,3-butadiene 
• 129529-63-1 (E)-7-chloro-2-ethylidene-4,6-dimethoxy-3(2H)-benzofuranone 
• 17793-63-4 (+)-dihydroepigriseofulvin 

Downstream Products

• 126-07-8 griseofulvin 
• 126-07-8 griseofulvin 
• 17793-65-6 (-)-2'-demethoxy-2',3'-dihydroepigriseofulvin 

Relevant articles and documents

Syntheses and antifungal activity of dl-griseofulvin and its congeners. II

Griseofulvin derivatives, dl-6'-demethyl-6'-ethylgriseofulvin (dl-5) and dl-6'-demethyl-6'-phenylgriseofulvin (dl-6) were prepared by application of a synthetic method developed by us. Antifungal activity of these derivatives decreased in the order of dl-

An improved synthetic method for dl-griseofulvin and its 2'-s-analogue

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Microbial transformation of (+)- and (-)-2'-demethoxydehydrogriseofulvin by Streptomyces cinereocrocatus

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