78790-79-1

Basic information

• Product Name: 3-AMINO-4-CYANOPYRIDINE
• Synonyms: 3-AMINO-ISONICOTINONITRILE;3-AMINO-4-PYRIDINECARBONITRILE;3-AMINO-4-CYANOPYRIDINE;4-Pyridinecarbonitrile,3-amino-(9CI);3-aminopyridine-4-carbonitrile;4-Pyridinecarbonitrile, 3-amino-;3-Aminoisonicotinonitrile 96%;3-Aminopyridine-4-carbonitrile, 3-Amino-4-cyanopyridine
• CAS NO: 78790-79-1
• Molecular Formula: C₆H₅N₃
• Molecular Weight: 119.12
• Product Categories: NITRILE;Pyridine series;Amines;Pyridines;Heterocycle-Pyridine series
• Mol File: 78790-79-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 135-138℃
• Boiling Point: 332.891 °C at 760 mmHg
• Flash Point: 155.127 °C
• Appearance: /
• Density: 1.236 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.81±0.18(Predicted)
• CAS DataBase Reference: 3-AMINO-4-CYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4-CYANOPYRIDINE(78790-79-1)
• EPA Substance Registry System: 3-AMINO-4-CYANOPYRIDINE(78790-79-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: 6.1
• Hazardous Substances Data: 78790-79-1(Hazardous Substances Data)

Usage

General Description

3-Amino-4-Cyanopyridine is a chemical compound, primarily used as an intermediate in organic synthesis. It is categorized under the pyridine family, represented by the chemical formula C6H6N2. The compound provides a structural backbone for various chemical reactions, particularly in the pharmaceutical industry where it can be used in the construction of vitamins and drugs. It features both an amino and a cyanide functional group making it bioactive and hence can participate in biochemical reactions. It should be handled cautiously due to its potential for toxic effects.

InChI:InChI=1/C6H5N3/c7-3-5-1-2-9-4-6(5)8/h1-2,4H,8H2

Upstream product

• 78790-80-4 3-Azido-4-cyanopyridine 
• 68325-15-5 3-chloro-isonicotinonitrile 
• 103698-09-5 4-cyano-3-nitropyridine 

Downstream Products

• 21038-67-5 pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione 
• 64188-97-2 3-aminopyridine-4-carboxamide 
• 1260674-57-4 (3-aminopyridin-4-yl)(3,4-dimethoxylphenyl)methanone 
• 1361569-49-4 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrido[3,4-d]pyrimidin-4-amine 
• 1384175-66-9 8-nitro-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile 
• 147055-80-9 4-cyano-3-mercaptopyridine 
• 160892-22-8 2-(2-fluorophenyl)pyrido<4,3-e><1,2,4>triazolo<1,5-c>pyrimidine 
• 160892-28-4 3-amino-4-<3-(2-fluorophenyl)-1H-<1,2,4>triazol-5-yl>pyridine 
• 144288-49-3 3-amino-4-(aminomethyl)pyridine 
• 160892-20-6 3-(2-fluorobenzoylamino)-4-iminopyrido<3,4-d>pyrimidine 

Relevant articles and documents

Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors

New series of Huprine (12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinolines) derivatives have been synthesized and their inhibiting activities toward recombinant human acetylcholinesterase (rh-AChE) are reported. We have synthesized two series of Huprine analogues; in the first one, the benzene ring of the quinoline moiety has been replaced by different heterocycles or electron-withdrawing or electron-donating substituted phenyl group. The second one has been designed in order to evaluate the influence of modification at position 12 where different short linkers have been introduced on the Huprine X, Y skeletons. All these molecules have been prepared from ethyl- or methyl-bicyclo[3.3.1]non-6-en-3-one via Friedlaender reaction involving selected o-aminocyano aromatic compounds. The synthesis of two heterodimers based on these Huprines has been also reported. Activities from moderate to same range than the most active Huprines X and Y taken as references have been obtained, the most potent analogue being about three times less active than parent Huprines X and Y. Topologic data have been inferred from molecular dockings and variations of activity between the different linkers suggest future structural modifications for activity improvement.

Preparation of 4-substituted 3-amino-2-chloropyridines, synthesis of a nevirapine analogue

A new method for preparing 3-amino-2-chloropyridines with a substituent (methyl, phenyl, carboxamide, methoxycarbonyl, acetyl, benzoyl and cyano) at the 4-position has been developed. An isoquinoline analogue of the reverse transcriptase inhibitor Nevirapine has been synthesized from the 4-amino-3-chloroisoquinoline.