78840-04-7

Basic information

• Product Name: 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE
• Synonyms: 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE;(2,5-dimethoxy-1,3-phenylene)dimethanol
• CAS NO: 78840-04-7
• Molecular Formula: C₁₀H₁₄O₄
• Molecular Weight: 198.22
• Mol File: 78840-04-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 109 °C
• Boiling Point: 364.1 °C at 760 mmHg
• Flash Point: 174 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 6.12E-06mmHg at 25°C
• Refractive Index: 1.549
• Solubility: soluble in Acetone
• CAS DataBase Reference: 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE(78840-04-7)
• EPA Substance Registry System: 2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE(78840-04-7)

Safety Data

• Hazardous Substances Data: 78840-04-7(Hazardous Substances Data)

Usage

General Description

2,6-BIS(HYDROXYMETHYL)-1,4-DIMETHOXYBENZENE is a chemical compound with the molecular formula C10H14O4. It is a white crystalline solid that is used primarily as a cross-linking agent in the production of resins and adhesives. It is also utilized as an intermediate in the synthesis of pharmaceuticals and other organic compounds. This chemical has a variety of industrial applications, including use in the production of plastics, coatings, and polymers. It is important to handle this compound with caution as it may be harmful if ingested or inhaled, and can cause skin and eye irritation.

InChI:InChI=1/C10H14O4/c1-13-9-3-7(5-11)10(14-2)8(4-9)6-12/h3-4,11-12H,5-6H2,1-2H3

Upstream product

• 150-76-5 4-methoxy-phenol 
• 21893-97-0 2,6-bis(hydroxymethyl)-4-methoxyphenol 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 120475-86-7 1,3-bis(hydroxymethyl)-2,5-dimethoxybenzene bis(hydrogen succinate) 
• 72652-35-8 1,3-bis-bromomethyl-2,5-dimethoxy-benzene 
• 120475-85-6 (2,5-dimethoxy-1,3-phenylene)bis(methylene) diacetate 
• 1356585-99-3 (1,3-di-tert-butyldimethylsilyloxymethyl)-4-iodo-2,5-dimethoxybenzene 
• 1356586-07-6 1,3-bis(hydroxymethyl)-4-iodo-2,5-dimethoxybenzene 
• 87050-69-9 3-(chloromethyl)-2,5-dimethoxybenzyl alcohol 
• 14538-50-2 1,3-dimethyl-2,5-dimethoxybenzene 
• 142823-16-3 C₆₀H₄₆N₄O₁₁ 
• 142823-16-3 C₆₀H₄₆N₄O₁₁ 
• 87050-76-8 (E)-1,2-bis<3-<(acetoxy)methyl>-2,5-dimethoxyphenyl>ethene 
• 87050-77-9 (Z)-1,2-bis<3-<(acetoxy)methyl>-2,5-dimethoxyphenyl>ethene 
• 87050-70-2 <2,5-dimethoxy-3-(hydroxymethyl)benzyl>triphenylphosphonium chloride 
• 87050-78-0 1,2-bis<3-<(acetyloxy)methyl>-2,5-dimethoxyphenyl>ethane 
• 87050-82-6 2,2'-ethylenebis[6-(hydroxymethyl)-p-benzoquinone] diacetate 

Relevant articles and documents

Photoinduced DNA Interstrand Cross-Linking by Benzene Derivatives: Leaving Groups Determine the Efficiency of the Cross-Linker

We have synthesized and characterized two small libraries of 2-OMe or 2-NO2-benzene analogues 2a-i and 3a-i containing a wide variety of leaving groups. Irradiation of these compounds at 350 nm generated benzyl radicals that were spontaneously oxidized to

Studies on the total synthesis of lactonamycin: Synthesis of the CDEF ring system

A concise and efficient synthesis of the tetracyclic CDEF ring system of lactonamycin (1) is described. The key step involved the Lewis acid mediated, intramolecular Friedel-Crafts acylation of carboxylic acid 6 to produce the tetracyclic CDEF core struct

Bis(bioreductive) alkylating agents: Synthesis and biological activity in a nude mouse human carcinoma model

Chemical investigations leading to the construction of bis(bioreductive) alkylating agents having both conformationally restricted and mobile spacer regions are described. Two targets having the conformationally mobile ethylene spacer group, namely, 2,2'-ethylenebis[6-(hydroxymethyl)-p-benzoquinone] diacetate (3b) and 2,2'-ethylenebis[6-(bromomethyl)-p-benzoquinone] (3c), were studied in vivo and in vitro using an established epithelial/Burkitt lymphoma hybrid cell line (D98/HR1) previously shown to induce carcinomas in nude mice. Inactivity of both test compounds in vitro, the relative resistance of these cells to test drugs in vitro, and the selective antitumor properties of the bis(bromomethyl) analogue in vivo lead to the proposal that this compound undergoes bioreduction to an alkylating species in the hypoxic core of the tumor, thereby exerting its action.