78875-63-5

Basic information

• Product Name: 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID
• Synonyms: 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID;BUTTPARK 30\06-43;4-Phenyl-1,2,3-thiadiazol-5-carboxylic acid;5-Carboxy-4-phenyl-1,2,3-thiadiazole;4-phenyl-5-thiadiazolecarboxylic acid;4-phenylthiadiazole-5-carboxylic acid
• CAS NO: 78875-63-5
• Molecular Formula: C₉H₆N₂O₂S
• Molecular Weight: 206.22
• Mol File: 78875-63-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 150℃
• Boiling Point: 380°C at 760 mmHg
• Flash Point: 183.6°C
• Appearance: /
• Density: 1.44g/cm³
• Vapor Pressure: 1.88E-06mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID(78875-63-5)
• EPA Substance Registry System: 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID(78875-63-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 78875-63-5(Hazardous Substances Data)

Usage

General Description

4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID is a highly important chemical compound with numerous applications in the pharmaceutical and agrochemical industries. It belongs to the class of heterocyclic compounds and is known for its various biological activities. With its unique structure, this compound has been identified as a potential drug candidate for the treatment of various diseases and has also shown promising antimicrobial and antifungal properties. Additionally, it has been researched for its potential use as a corrosion inhibitor in industrial applications. These diverse properties make 4-PHENYL-1,2,3-THIADIAZOLE-5-CARBOXYLIC ACID a valuable and versatile chemical compound with a wide range of potential applications.

InChI:InChI=1/C9H6N2O2S/c12-9(13)8-7(10-11-14-8)6-4-2-1-3-5-6/h1-5H,(H,12,13)

Upstream product

• 58756-26-6 ethyl 4-phenyl-1,2,3-thiadiazole-5-carboxylate 

Downstream Products

• 78875-53-3 (4-Phenyl-[1,2,3]thiadiazol-5-yl)-p-tolyl-methanone 
• 1093255-55-0 N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-4-phenyl-1,2,3-thiadiazole-5-carboxamide 
• 78875-62-4 (4-Chloro-phenyl)-(4-phenyl-[1,2,3]thiadiazol-5-yl)-methanol 
• 78875-70-4 5-[Chloro-(4-chloro-phenyl)-methyl]-4-phenyl-[1,2,3]thiadiazole 
• 78875-69-1 5-(Chloro-p-tolyl-methyl)-4-phenyl-[1,2,3]thiadiazole 
• 78875-61-3 (4-Phenyl-[1,2,3]thiadiazol-5-yl)-p-tolyl-methanol 
• 78875-68-0 5-(Chloro-phenyl-methyl)-4-phenyl-[1,2,3]thiadiazole 
• 78875-60-2 Phenyl-(4-phenyl-[1,2,3]thiadiazol-5-yl)-methanol 
• 78875-52-2 phenyl 4-phenyl-1,2,3-thiadiazol-5-yl ketone 
• 78875-54-4 p-chlorophenyl 4-phenyl-1,2,3-thiadiazol-5-yl ketone 

Relevant articles and documents

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling non-regulated necrosis. This form of cell death can be induced in an array of cell types in apoptotic deficient conditions with death receptor family ligands. A series of [1,2,3]thiadiazole benzylamides was found to be potent necroptosis inhibitors (called necrostatins). A structure-activity relationship study revealed that small cyclic alkyl groups (i.e. cyclopropyl) and 2,6-dihalobenzylamides at the 4- and 5-positions of the [1,2,3]thiadiazole, respectively, were optimal. In addition, when a small alkyl group (i.e. methyl) was present on the benzylic position all the necroptosis inhibitory activity resided with the (S)-enantiomer. Finally, replacement of the [1,2,3]thiadiazole with a variety of thiophene derivatives was tolerated, although some erosion of potency was observed.