78907-06-9

Basic information

• Product Name: methyl (benzylamino)(phenyl)acetate
• CAS NO: 78907-06-9
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.3117
• Mol File: 78907-06-9.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 368.2°C at 760 mmHg
• Flash Point: 176.5°C
• Density: 1.114g/cm³
• Vapor Pressure: 1.29E-05mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: methyl (benzylamino)(phenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (benzylamino)(phenyl)acetate(78907-06-9)
• EPA Substance Registry System: methyl (benzylamino)(phenyl)acetate(78907-06-9)

Safety Data

• Hazardous Substances Data: 78907-06-9(Hazardous Substances Data)

Upstream product

• 67627-99-0 N-benzyliden-α-phenyl-glycine methyl ester 
• 100-52-7 benzaldehyde 
• 24461-61-8 phenylglycine methyl ester 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 2835-06-5 phenylglycin 
• 1005500-77-5 N,4-dimethyl-N-(phenylethynyl)benzenesulfonamide 
• 124-41-4 sodium methylate 
• 100-46-9 benzylamine 
• 22979-35-7 Methyl phenyldiazoacetate 
• 67-56-1 methanol 
• 780-25-6 N-benzylidene benzylamine 

Downstream Products

• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 100-52-7 benzaldehyde 
• 16116-46-4 1-benzyl-5-phenyl-imidazolidine-2,4-dione 
• 1200404-06-3 2-chloro-N-(4-(4-phenyl-5-(trifluoromethyl)oxazol-2-yl)phenyl)benzamide 
• 1200404-05-2 4-(4-phenyl-5-(trifluoromethyl)oxazol-2-yl)benzenamine 
• 1200404-04-1 2-(4-nitrophenyl)-4-phenyl-5-(trifluoromethyl)oxazole 
• 1200404-02-9 2-(N-benzyl-4-nitrobenzamido)-2-phenylacetic acid 
• 1200404-00-7 methyl 2-(N-benzyl-4-nitrobenzamido)-2-phenylacetate 
• 1233326-82-3 (R)-quinuclidin-3-yl 2-(benzylamino)-2-phenylacetate 
• 1859-51-4 N-Benzyl-α-phenylglycine 
• 86071-05-8 1-(α-methoxycarbonyl)benzyl-3-hydroxy-3-methyl-4-phenyl-2-azetidinone 
• 219906-60-2 1-benzyl-6-methoxycarbonyl-6-phenylpiperidine-2,5-dione 
• 219906-61-3 1-benzyl-6-phenylpiperidine-2,5-dione 
• 597558-93-5 methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate 

Relevant articles and documents

Benzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes

Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzoazepine-fused isoindolines. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramolecular (3 + 2)-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.

Catalytic Ynamide Oxidation Strategy for the Preparation of α-Functionalized Amides

A Lewis acid-catalyzed alkyne oxidation strategy has been developed to produce diverse α-functionalized amides from readily and generally available ynamides. An efficient zinc(II)-catalyzed oxidative azidation and thiocyanation has been achieved, providing facile access to synthetically useful α-azido amides and α-thiocyanate amides, respectively. This chemistry can also be extended to oxidative halogenations by employing the 2-halopyridine N-oxide as both the oxidant and the halogen source, and its mechanistic rationale is also supported by density functional theory calculations. Moreover, NaBARF has been demonstrated to catalyze such an alkyne oxidation effectively, thus further excluding the metal carbene pathway in this cascade reaction.

OXAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

The present invention relates generally to compounds represented in Formula (I), pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.