79-33-4Relevant articles and documents
γ-Valerolactone-introduced controlled-isomerization of glucose for lactic acid production over an Sn-Beta catalyst
Zhao, Xinpeng,Zhou, Zhimin,Luo, Hu,Zhang, Yanfei,Liu, Wang,Miao, Gai,Zhu, Lijun,Kong, Lingzhao,Li, Shenggang,Sun, Yuhan
supporting information, p. 2634 - 2639 (2021/04/22)
Combined experiments and density functional theory (DFT) calculations provided insights into the role of environment-friendly γ-valerolactone (GVL) as a solvent in the hydrothermal conversion of glucose into lactic acid (LA) over the post-synthesized Sn-Beta catalyst. By introducing 2.0 wt% GVL, a much higher yield of LA (72.0 wt%) was obtained than that in pure water (60.1 wt%) at 200 °C, 4 MPa N2, and 30 min in a batch reactor. The GVL effectively suppressed the isomerization of glucose into fructose in a controlled-transfer mode, resulting in a lower fructose concentration. Thermogravimetry-differential analysis and DFT calculations demonstrated that the competitive adsorption between GVL and glucose happened at the open Sn sites over the Sn-Beta catalyst, which led to a controlled isomerization rate in water. Further increasing the content of GVL to 20.0 wt%, the higher yield of LA (74.0 wt%) was attributed to the more efficient competitive adsorption while also inhibiting carbon deposition.
METHODS FOR SYNTHESIZING ANHYDROUS LACTIC ACID
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Paragraph 0038; 0056, (2021/11/13)
A method of synthesizing anhydrous lactic acid is provided by reacting a compound of formula (Ia): with an acid compound of formula HnX in a first solvent to produce a reaction mixture comprising a compound of formula (Ib) and a lactic acid compound of formula (I) in solution with the first solvent and/or water. n is an integer other than 0, x is 0, or an integer other than 0, M is an alkali metal or alkaline earth metal and X is the conjugate base of the acid compound of formula HnX. The resulting reaction mixture is filtered to produce a filtrate containing lactic acid in solution. The filtrate is crystalized from a second solvent to produce anhydrous lactic acid.
Epimerization-suppressed organocatalytic synthesis of poly-L-lactide in supercritical carbon dioxide under plasticizing conditions
Mase, Nobuyuki,Moniruzzaman,Yamamoto,Sato,Narumi, Tetsuo,Yanai, Hikaru
supporting information, (2019/08/06)
Herein, an efficient (>95% yield, >99.0% ee) Br?nsted acid-catalyzed synthetic method of poly-L-lactide (PLLA) in supercritical carbon dioxide (scCO2) under plasticizing conditions is presented. High-performance liquid chromatography analysis of the PLLA hydrolysis products indicated that, as opposed to the case of organic solvents, the use of a nucleophilic catalyst in scCO2 suppressed the epimerization. The highly stereochemically pure PLLA prepared by the developed method under metal-free conditions meets the criteria of medicinal/engineering applications.