790184-33-7

Basic information

• Product Name: (R)-2-Methylmorpholine
• Synonyms: (R)-2-Methyl-morpholine;Morpholine, 2-Methyl-, (2R)-
• CAS NO: 790184-33-7
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Mol File: 790184-33-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 137℃
• Flash Point: 41℃
• Appearance: /
• Density: 0.891
• PKA: 9.01±0.40(Predicted)
• CAS DataBase Reference: (R)-2-Methylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-Methylmorpholine(790184-33-7)
• EPA Substance Registry System: (R)-2-Methylmorpholine(790184-33-7)

Safety Data

• Hazardous Substances Data: 790184-33-7(Hazardous Substances Data)

Usage

General Description

(R)-2-Methylmorpholine, also known as Methylmorpholine, is an organic compound belonging to the class of morpholine derivatives. It is a colorless liquid with a faint amine odor and is highly soluble in water. This chemical is used as a solvent, catalyst, and corrosion inhibitor in various applications such as in the manufacturing of pharmaceuticals, agrochemicals, and rubber chemicals. It is also used in the production of polyurethane foams and as a stabilizer in the dyeing process. Additionally, (R)-2-Methylmorpholine is known for its strong base and nucleophilic properties, making it valuable in organic synthesis and as a reactant in the production of different chemical compounds. However, it is important to handle this chemical with caution as it can be hazardous if not properly managed.

Upstream product

• 120800-90-0 (R)-4-benzyl-2-methylmorpholine 
• 127958-66-1 (6R)-6-methylmorpholin-3-one 
• 454251-71-9 (2S,4aS,7R,8aR)-N-allyl-2-hydroxymethyl-4,4,7-trimethyl-octahydro-1,3-benzoxazine 
• 914359-85-6 (3S,6aS,9R,10aR,11aS)-3-phenylselenenylmethyl-6,6,9-trimethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine 
• 914360-11-5 (2R)-4-(8-mentholyl)-2-methyl-morpholine 
• 914359-99-2 (3R,6aS,9R,10aR,11aS)-3,6,6,9-tetramethyl-decahydro-3H,7H-[1,4]oxazino[3,4-b][1,3]benzoxazine 

Downstream Products

• 1257234-85-7 2-[(2R)-2-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide 
• 1257234-87-9 2-[(2S)-2-methylmorpholin-4-yl]-N-[6-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-2-yl]acetamide 
• 1257234-97-1 2-[(2R)-2-methylmorpholin-4-yl]-N-[6-(2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)dibenzothiophen-2-yl]acetamide 
• 1257234-83-5 N-methyl-2-[(2R)-2-methylmorpholin-4-yl]-N-[6-(2-morpholin-4-yl-4-oxopyrido[1,2-a]pyrimidin-9-yl)dibenzo[b,d]thiophen-2-yl]acetamide 

Relevant articles and documents

Preparation method of chiral morpholine compound

The invention provides a preparation method of a chiral morpholine compound. With chiral ethylene oxide as a raw material, the preparation method comprises the steps of ring opening, cyclization and deprotection reaction to obtain the chiral 2-substituted morpholine compound. The preparation process is simple and environmentally friendly, has mild reaction conditions, is free of irritation or allergens, has higher total yield and good safety and is suitable for industrial amplification.

DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS

Compound formula I: wherein: X1 and X2 may be either (a) C and O, (b) N and N, or (c) C and NH, where the dotted bonds represents a double bond in the appropriate location; R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; RN1 is selected from hydrogen and an optionally substituted C1-4 alkyl group; RC1 is selected from an optionally substituted C1-7 alkyl group, an optionally substituted C3-20 heterocyclyl group, or an optionally substituted C5-20 aryl group; or RN1 and RC1 may together form an optionally substituted C2-4 alkylene group.