791028-27-8 Usage
Description
α-amine-ω-propionic acid diethylene glycol, also known as Amino-PEG2-acid, is a PEG reagent that contains an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer enhances its solubility in aqueous media, while the reactive amino group can interact with carboxylic acids, activated NHS esters, and carbonyls (ketone, aldehyde). The terminal carboxylic acid is capable of reacting with primary amine groups in the presence of activators such as EDC or HATU to form a stable amide bond.
Uses
Used in Bioconjugation:
α-amine-ω-propionic acid diethylene glycol serves as a bioconjugation agent for the formation of stable amide bonds between primary amine groups and the terminal carboxylic acid. This makes it suitable for linking biological molecules, such as proteins, peptides, or antibodies, to other molecules or surfaces.
Used in Drug Delivery Systems:
In the pharmaceutical industry, α-amine-ω-propionic acid diethylene glycol is utilized as a component in drug delivery systems. Its hydrophilic PEG spacer improves the solubility and stability of drug formulations, while the reactive groups facilitate the attachment of drug molecules to carriers or targeting moieties.
Used in Diagnostic Imaging:
α-amine-ω-propionic acid diethylene glycol is employed in diagnostic imaging as a contrast agent or a component of imaging probes. The PEG spacer enhances the solubility and biocompatibility of these agents, while the reactive groups allow for the attachment of imaging reporter groups or targeting ligands.
Used in Cosmetics and Personal Care:
In the cosmetics and personal care industry, α-amine-ω-propionic acid diethylene glycol is used as an ingredient to improve the solubility, stability, and biocompatibility of various formulations. Its reactive groups can be used to attach active ingredients or functional moieties to enhance the performance of cosmetic products.
Used in Material Science:
In material science, α-amine-ω-propionic acid diethylene glycol is utilized in the development of functional polymers and materials. The PEG spacer and reactive groups enable the creation of materials with tailored properties, such as self-healing polymers, stimuli-responsive materials, or surfaces with specific binding capabilities.
Biological Activity
Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADClinker for the synthesis of antibody-drug conjugated Ck (ADC). It is also a PEG-based PROTAClinker that can be used for PROTAC synthesis.
in vivo
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Check Digit Verification of cas no
The CAS Registry Mumber 791028-27-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,9,1,0,2 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 791028-27:
(8*7)+(7*9)+(6*1)+(5*0)+(4*2)+(3*8)+(2*2)+(1*7)=168
168 % 10 = 8
So 791028-27-8 is a valid CAS Registry Number.
791028-27-8Relevant articles and documents
CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES
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Paragraph 00605-00606, (2021/07/17)
The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a mannose-6-phosphate receptor (M6PR) or a cell surface asialoglycoprotein receptor (ASGPR). The cell surface M6PR or ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., M6PR or ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.
