79349-82-9Relevant articles and documents
One-step environment-friendly preparation method of 7-amino-3-vinyl cephalosporanic acid
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Paragraph 0024; 0032-0035; 0037-0039; 0041-0043; 0045-0047, (2020/09/08)
The invention discloses a one-step environment-friendly preparation method of 7-amino-3-vinyl cephalosporanic acid. The method comprises the following steps: A, uniformly mixing an aprotic organic solvent with water, adding D-7-ACA and an alkaline agent A, dissolving, and adding pyridine chlorochromate or Desmatin iodine pyrane; B, adding methyltriphenylphosphonium bromide into an aprotic organicsolvent, dissolving, adding the reaction solution obtained in the previous step, slowly dropwise adding an alkaline agent B, and reacting to obtain a solution containing a target product salt; and C,adjusting the pH value of the reaction system to 3.5-4.5, separating out a solid, filtering, washing and drying to obtain the product. The researched and developed preparation process has the technical advantages of environmental friendliness, high atom utilization rate, few byproducts, high production efficiency, low production cost and the like.
A 7 - amino - 3 - vinyl - 4 - cephalosporanic acid preparation method (by machine translation)
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Paragraph 0021-0022; 0025-0026; 0027-0028; 0029-0032, (2018/01/11)
The invention discloses a 7 - amino - 3 - vinyl - 4 - cephalosporanic acid preparation method, in order to 7 - phenylacetylamino - 3 - vinyl - 4 - cephalosporanic acid-methoxybenzyl ester as the raw material, to solid super strong acid as catalyst, in the alkyl halide, acetate and acetonitrile in the mixed solvent, in the 0 - 50 °C reaction at a temperature of 1 - 10 hours, the reaction is cooled down to the room temperature after treatment to obtain yellow solid, to obtain the target product, solid super strong acid as transition metal modified tin series solid super strong acid; alkyl halide is carbon atom number 1 - 10 of the chlorine; b ester as CH3 COOR, wherein R is a carbon atom number 1 - 10 alkane. This invention adopts the heterogeneous catalysis in a one-pot reaction technology, the use of high activity of the solid acid catalyst for the preparation of 7 - amino - 3 - vinyl - 4 - cephalosporanic acid, this technology is easy to operate, does not corrode the apparatus, three wastes, after treatment is convenient, solid acid can be used repeatedly, is an economic and practical and environmental protection. (by machine translation)
7-phenylacetylamino-3-vinyl-4- spore olefine acid method for the preparation of P-methoxybenzyl ester
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Paragraph 0032-0034, (2017/02/17)
The invention discloses a preparation method of 7-phenylacetamido-3-vinyl-4-p-methoxy benzyl ester cefotaximate and belongs to the Chemical medicine field. The preparation method comprises the following steps: carrying out quaternary phosphorization and vinyl reaction at the same time on 7-phenylacetamido-3-chloromethyl-4-p-methoxy benzyl ester cefotaximate (GCLE), sodium iodide, triphenylphosphine and formaldehyde solution in a mixed system of dichloromethane, acetone and water to obtain 7-phenylacetamido-3-vinyl-4-p-methoxy benzyl ester cefotaximate; and removing 7-amino and 4-carboxyl protecting group according to known methods to prepare cefixime and cefdinir nuclear parent 7-AVCA (7-amino-3-vinyl-4-cephalosporanic acid). The aqueous phase comprising sodium iodide and excessive formaldehyde can be repeatedly applied, so that the utilization ratio of sodium iodide is remarkably improved, the production cost is lowered, and the environmental pollution caused by formaldehyde is reduced. The preparation method disclosed by the invention is low in production cost, simple in operating method and suitable for industrialized production and the raw materials are easily available in the preparation process.