79371-66-7Relevant articles and documents
Characterization of new bisphenol A metabolites produced by CD1 mice liver microsomes and S9 fractions
Jaeg, Jean Philippe,Perdu, Elisabeth,Dolo, Laurence,Debrauwer, Laurent,Cravedi, Jean-Pierre,Zalko, Daniel
, p. 4935 - 4942 (2004)
Bisphenol A [2,2-bis(4-hydroxyphenyl)propane] (BPA) is a widely used industrial chemical resulting in occupational and consumer exposure. BPA possesses weak estrogenomimetic activity and can be cytotoxic, though the underlying mechanisms of its toxicity toward cells are not completely understood. The metabolism of BPA by CD1 mice liver microsomal and S9 fractions was investigated. Nine metabolites were isolated and characterized using HPLC and mass spectrometry. Many of these metabolites were characterized for the first time in mammals, namely isopropyl-hydroxyphenol (produced by the cleavage of BPA), a bisphenol A glutathione conjugate, glutathionyl-phenol, glutathionyl 4-isopropylphenol, and BPA dimers. Most of these metabolites apparently share a common metabolic pathway, for which considerable evidence supports the hypothesis of the production of a reactive intermediate, and also helps explain BPA cytotoxicity.
Photo-oxidation of bisphenol A in aqueous solutions at near neutral pH by a Fe(III)-carboxylate complex with oxalacetic acid as a benign molecule
Xu, Jing,Zhao, Chuxuan,Wang, Tianbei,Yang, Shaojie,Liu, Zizheng
, (2018/06/06)
The photo-oxidation of organic pollutants as induced by ferric-carboxylate complexes was known to be a photo-Fenton-like process. The use of a carboxylate ligand with higher efficiency and lower toxicity at near neutral pH is of high interest to researchers. In this work, photo-oxidation of bisphenol A (BPA) induced by a ferric-oxalacetic acid complex in aqueous solutions was investigated under 395 nm LED lamps. The results showed that the rate of BPA degradation increased in the order pH 10.0 8.0 6.5 4.0 within the first 10 min. More than 90% of BPA was successfully oxidized with Fe(III)/oxalacetic acid with a ratio of 1:5 at pH 6.5, which was primarily attributed to the generated hydroxyl radical. Iron in the Fe(III)-oxalacetic acid system was reused by simple addition of oxalacetic acid to the reaction mixture. Compared to common carboxylate ligands (pyruvic acid, oxalic acid, and citric acid), oxalacetic acid is more efficient and environmentally friendly for the Fe(III)-carboxylate complex-based photo-Fenton-like process at near neutral pH.
Preparation of nitrogen doped K2Nb4O11 with high photocatalytic activity for degradation of organic pollutants
Qiu, Yongfu,Wang, Lei,Leung, Chi-Fai,Liu, Guijian,Yang, Shihe,Lau, Tai-Chu
experimental part, p. 23 - 30 (2012/04/10)
Nitrogen doped K2Nb4O11 (K 2Nb4O11-N) has been prepared by solid state reaction between K2Nb4O11 and urea at 400 °C. K2Nb4O11-N has been characterized by XRD, SEM, XPS and UV/vis diffuse reflectance. The photodegradation of various organic pollutants in water by this material, including Orange G (OG), bisphenol A (BPA) and pentachlorophenol (PCP) have been studied at λ > 330 nm and >399 nm. The results show that the photocatalytic activity of K 2Nb4O11-N at >399 nm is higher than those of K2Nb4O11 and Degussa TiO2 P25, indicating the activating effect of nitrogen doping. A mechanism for the photodegradation of organic substrates by K2Nb4O 11-N is proposed.