794522-90-0

Basic information

• Product Name: 4-PyriMidineacetonitrile
• Synonyms: 4-PyriMidineacetonitrile;2-(PyriMidin-4-yl)acetonitrile
• CAS NO: 794522-90-0
• Molecular Formula: C₆H₅N₃
• Molecular Weight: 119.124
• Mol File: 794522-90-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-PyriMidineacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PyriMidineacetonitrile(794522-90-0)
• EPA Substance Registry System: 4-PyriMidineacetonitrile(794522-90-0)

Safety Data

• Hazardous Substances Data: 794522-90-0(Hazardous Substances Data)

Usage

General Description

4-Pyrimidineacetonitrile is a chemical compound with the molecular formula C6H4N2. It is a heterocyclic compound that contains a pyrimidine ring and a nitrile group. 4-PyriMidineacetonitrile is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, as well as in the production of dyes and other organic compounds. It has potential applications in the pharmaceutical industry, particularly in the development of anti-cancer and anti-inflammatory drugs. 4-Pyrimidineacetonitrile is a versatile building block in organic synthesis and has attracted interest from researchers for its potential in drug development and material science.

Upstream product

• 179009-23-5 (E)-N,N-dimethyl-2-(pyrimidin-4-yl)ethen-1-amine 
• 3438-46-8 4-Methylpyrimidine 
• 7677-24-9 trimethylsilyl cyanide 
• 54198-81-1 4-pyrimidinylmethyl chloride 
• 36912-83-1 1-phenyl-2-(pyrimidin-4-yl)ethan-1-one 

Downstream Products

• 897644-70-1 5-amino-3-(4-fluorophenyl)-4-(4-pyrimidinyl)isoxazole 
• 897645-25-9 5-amino-3-(2-chlorophenyl)-4-(4-pyrimidinyl)isoxazole 
• 897645-33-9 5-amino-3-(4-chlorophenyl)-4-(4-pyrimidinyl)isoxazole 
• 897645-82-8 5-amino-3-(2,4-difluorophenyl)-4-(4-pyrimidinyl)isoxazole 
• 897646-06-9 5-amino-3-(2,6-difluorophenyl)-4-(4-pyrimidinyl)isoxazole 
• 897646-36-5 5-amino-3-(2,6-dichlorophenyl)-4-(4-pyrimidinyl)isoxazole 
• 897647-04-0 5-amino-3-(3-methylphenyl)-4-(4-pyrimidinyl)isoxazole 
• 897647-50-6 5-amino-3-(4-fluoro-3-methyl)-4-(4-pyrimidinyl)isoxazole 

Relevant articles and documents

Modulating Photostability and Mitochondria Selectivity in Far-Red/NIR Emitting Coumarin Fluorophores through Replacement of Pyridinium by Pyrimidinium

Mitochondrial dysfunction has been associated with several human pathological conditions, including cancer, aging, and neurodegenerative diseases. Thus, the availability of selective fluorescent probes for mitochondria could play an important role in the future for monitoring cellular functions and disease progression. In this work, we have studied how the photophysical properties and subcellular accumulation of nonconventional coumarin-based COUPY fluorophores can be fine-tuned through replacement of the para-pyridinium moiety with several heterocycles. Among them, ortho,para-pyrimidinium substitution provided novel fluorophores with suitable photophysical properties for bioimaging applications, including emission in the far-red to NIR region, large Stokes' shifts, and high photostability. Furthermore, the compounds exhibited excellent cell membrane permeability in living cells and a higher selectivity for mitochondria compared with the parent COUPY fluorophores. Overall, these results provided useful insights into the development of novel mitochondria-targeted fluorescent probes based on small organic molecules, since higher selectivity for this organelle can be achieved through the replacement of conventional N-alkylated pyridinium moieties by the corresponding N-alkylated-ortho,para-pyrimidinium counterparts.

FTO INHIBITORS

The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

TREATMENT AGENT FOR INFLAMMATORY BOWEL DISEASE

The invention discloses treating agents of inflammatory bowel disease, which contain p38MAPkinase inhibitor having properties of antedrug as the active ingredient.