79547-07-2Relevant articles and documents
A new and efficient method for the synthesis of 3-(2-nitrophenyl)pyruvic acid derivatives and indoles based on the Reissert reaction
Mamedov, Vakhid A.,Mamedova, Vera L.,Syakaev, Victor V.,Khikmatova, Gul'naz Z.,Korshin, Dmitry E.,Kushatov, Temur A.,Latypov, Shamil K.
, p. 3923 - 3925 (2018/10/02)
The formation of 3-(2-nitrophenyl)pyruvic acid and its amide and ester derivatives – key compounds for the Reissert indole synthesis – was achieved under various reaction conditions via the acid catalyzed hydrolysis of 5-(2-nitrobenzyliden)-2,2-dimethyl-1,3-oxazolidin-4-one, which is readily available from 3-(2-nitrophenyl)oxirane-2-carboxamide. A new and highly efficient method for the synthesis of indole-2-carboxylic acid derivatives via the intramolecular reductive cyclization of o-nitrophenylpyruvic acid and its amide and ester derivatives was developed using Na2S2O4 in dioxane/water at reflux.
Synthesis of new highly substituted and hindered 1-hydroxyindole-2-carboxylates
Park, Yeon Kyeong,Kim, Hyejin,Lee, Sang Hyup
, p. 82 - 90 (2016/01/20)
The synthesis of new, highly substituted, and hindered 1-hydroxyindole-2-carboxylates 1 is described. Substrates 2, prepared through a two-step synthetic sequence, were treated with relatively weak nucleophiles in the presence of SnCl2 · 2H2O to afford compounds 1. In particular, nucleophiles of low reactivity and/or high steric hindrance reacted efficiently to give 1 in good to modest yields.
COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
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Page/Page column 35-36, (2011/06/11)
The present invention concerns compounds, some of which are novel, and their pharmaceutical applications. The compounds of the invention inhibit the enzyme lactate dehydrogenase (LDH) involved both in the metabolic process of hypoxic tumour cells, and in the process used by parasitic protozoa that cause malaria to obtain most of the energy they need.
