79640-73-6

Basic information

• Product Name: N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-n-butylamide
• Synonyms: N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-n-butylamide
• CAS NO: 79640-73-6
• Molecular Weight: 392.495
• Mol File: 79640-73-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-n-butylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-n-butylamide(79640-73-6)
• EPA Substance Registry System: N-(tert-butyloxycarbonyl)-L-glutamic acid α-benzyl ester γ-n-butylamide(79640-73-6)

Safety Data

• Hazardous Substances Data: 79640-73-6(Hazardous Substances Data)

Upstream product

• 30924-93-7 Boc-Glu-OBn 
• 109-73-9 N-butylamine 

Downstream Products

• 79640-79-2 L-glutamic acid α-benzyl ester γ-n-butylamide p-toluenesulfonate salt 

Relevant articles and documents

Methotrexate Analogues. 14. Synthesis of New γ-Substituted Derivatives as Dihydrofolate Reductase Inhibitors and Potential Anticancer Agents

The γ-tert-butyl ester (1), γ-hydrazide (2), γ-n-butylamide (3), and γ-benzylamide (4) derivatives of methotrexate (MTX) were synthesized from 4-amino-4-deoxy-N10-methylpteroic acid (APA) and the appropriate blocked L-glutamic acid precursors with the aid of the peptide bond forming reagent diethyl phosphorocyanidate.The affinity of these side chain modified products for dihydrofolate reductase (DHFR) from Lactobacillus casei and L1210 mouse leukemic cells was determined spectrophotometrically or by competitive radioligand binding assay, and their cytotoxicity was evaluated against L1210 leukemic cells in culture.The results provide continuing support for the view that the "γ-terminal region" of the MTX side chain is an attractive site for molecular modification of this anticancer agent.