796600-15-2

Basic information

• Product Name: 2-chloro-4-fluoro-3-methylbenzonitrile
• Synonyms: 2-chloro-4-fluoro-3-methylbenzonitrile;2-chloro-3-methyl-4-fluorobenzonitrile;Benzonitrile, 2-chloro-4-fluoro-3-methyl-
• CAS NO: 796600-15-2
• Molecular Formula: C₈H₅ClFN
• Molecular Weight: 169.585
• Mol File: 796600-15-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 260.751 °C at 760 mmHg
• Flash Point: 111.498 °C
• Appearance: /
• Density: 1.283 g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-chloro-4-fluoro-3-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-fluoro-3-methylbenzonitrile(796600-15-2)
• EPA Substance Registry System: 2-chloro-4-fluoro-3-methylbenzonitrile(796600-15-2)

Safety Data

• Hazardous Substances Data: 796600-15-2(Hazardous Substances Data)

Usage

Uses

2-Chloro-4-fluoro-3-methylbenzonitrile is a reagent used in the synthesis of a novel and potent nonsteroidal androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.

InChI:InChI=1/C8H5ClFN/c1-5-7(10)3-2-6(4-11)8(5)9/h2-3H,1H3

Upstream product

• 60702-69-4 2-chloro-4-fluorobenzonitrile 
• 74-88-4 methyl iodide 
• 203302-92-5 3-bromo-2-chloro-6-fluorotoluene 
• 924626-56-2 2-chloro-4-fluoro-3-methylbenzamide 
• 557-21-1 dicyanozinc 

Downstream Products

• 899821-23-9 ACP-105 
• 1182367-37-8 (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxypropanoic acid 
• 1182367-29-8 (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxy-3-methylbutanoic acid 
• 1182366-72-8 (2R,3R)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid 
• 1182369-21-6 (R)-2-(3-chloro-4-cyano-2-methylphenylamino)-4-hydroxybutanoic acid 
• 1030898-99-7 2-chloro-4-[(2S,3S)-3-hydroxy-2,3-dimethylpyrrolidin-1-yl]-3-methylbenzonitrile 

Relevant articles and documents

2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy

A transdermal SARM has a potential to have therapeutic benefit through anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) and liver-mediated decrease in HDL-C. 2-Chloro-4-[(2-hydroxy-2-methyl-cyclopentyl)amino

Synthesis, structure-activity relationships, and characterization of novel nonsteroidal and selective androgen receptor modulators

Herein we describe the discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound 1 was developed from a series of compounds found in a HTS screen using the receptor selection and amplification technology (R-SAT). In vivo, 1 improved anabolic parameters in a 2-week chronic study in castrated male rats. In addition to compound 1, a number of potent antiandrogens were discovered from the same series of compounds whereof one compound, 13, had antagonist activity at the AR T877A mutant involved in prostate cancer.

SUBSTITUTED N-ARYLPYRROLIDINES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS

The present invention provides a compound of the formula: Formula I or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly frailty, osteoporosis, osteopenia, and male and female sexual dysfunction comprising administering to a patient in need thereof an effective amount of a compound of Formula I.