79698-53-6

Basic information

• Product Name: (3-Chloropyridin-4-yl)methanol
• Synonyms: (3-Chloropyridin-4-yl)methanol;3-Chloro-4-pyridinemethanol;3-CHLoro-4-(hydroxyMethyl)pyridine
• CAS NO: 79698-53-6
• Molecular Formula: C6H6ClNO
• Molecular Weight: 143.57
• Product Categories: pharmacetical
• Mol File: 79698-53-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 114-115℃
• Boiling Point: 261℃
• Flash Point: 112℃
• Appearance: /
• Density: 1.324
• Vapor Pressure: 0.00603mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: 2-8°C
• PKA: 12.77±0.10(Predicted)
• CAS DataBase Reference: (3-Chloropyridin-4-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Chloropyridin-4-yl)methanol(79698-53-6)
• EPA Substance Registry System: (3-Chloropyridin-4-yl)methanol(79698-53-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 79698-53-6(Hazardous Substances Data)

Usage

General Description

(3-Chloropyridin-4-yl)methanol, also known as 3-chloro-4-pyridylmethanol, is a chemical compound with the molecular formula C6H6ClNO. It is a white to off-white solid that is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. (3-Chloropyridin-4-yl)methanol has a variety of applications, including as a building block in the production of active pharmaceutical ingredients and as a starting material for the synthesis of various heterocyclic compounds. Additionally, it may also be used in research and development efforts in the pharmaceutical and agrochemical industries. It is important to handle (3-Chloropyridin-4-yl)methanol with care, as it may present hazards such as skin and eye irritation, and it should be stored and used in a well-ventilated area in accordance with safety guidelines.

InChI:InChI=1/C6H6ClNO/c7-6-3-8-2-1-5(6)4-9/h1-3,9H,4H2

Upstream product

• 98273-79-1 3-chloropyridine-4-carboxylic acid methyl ester 
• 88912-27-0 3-chloro-isonicotinic acid 
• 72990-37-5 3-chloro-4-pyridinecarboxyaldehyde 
• 626-60-8 3-Chloropyridine 
• 109-94-4 formic acid ethyl ester 

Relevant articles and documents

Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R

Tumor-associated macrophages (TAMs) have a significant presence in the tumor stroma across multiple human malignancies and are believed to be beneficial to tumor growth. Targeting CSF1R has been proposed as a potential therapy to reduce TAMs, especially the protumor, immune-suppressive M2 TAMs. Additionally, the high expression of CSF1R on tumor cells has been associated with poor survival in certain cancers, suggesting tumor dependency and therefore a potential therapeutic target. The CSF1-CSF1R signaling pathway modulates the production, differentiation, and function of TAMs; however, the discovery of selective CSF1R inhibitors devoid of type III kinase activity has proven to be challenging. We discovered a potent, highly selective, and orally bioavailable CSF1R inhibitor, IACS-9439 (1). Treatment with 1 led to a dose-dependent reduction in macrophages, promoted macrophage polarization toward the M1 phenotype, and led to tumor growth inhibition in MC38 and PANC02 syngeneic tumor models.

Methanol as hydrogen source: Transfer hydrogenation of aromatic aldehydes with a rhodacycle

A cyclometalated rhodium complex has been shown to perform highly selective and efficient reduction of aldehydes, deriving the hydrogen from methanol. With methanol as both the solvent and hydrogen donor under mild conditions and an open atmosphere, a wide range of aromatic aldehydes were reduced to the corresponding alcohols, without affecting other functional groups.

NOXIOUS ARTHROPOD CONTROL COMPOSITION AND HETEROCYCLIC COMPOUND

A noxious arthropod controlling composition comprising a heterocyclic compound represented by the formula (1) [wherein, A1 and A2 represent ═C(R6)—, nitrogen and so on, R1 represents a halogen and so on, R3