79757-92-9

Basic information

• Product Name: (4'-METHYLBIPHENYL-4-YL)-METHANOL
• Synonyms: [4-(4-METHYLPHENYL)PHENYL]METHAN-1-OL;(4'-METHYL[1,1'-BIPHENYL]-4-YL)METHANOL;(4'-METHYLBIPHENYL-4-YL)-METHANOL;AKOS BAR-1214;RARECHEM AL BD 1278;4-(4-Tolyl)benzyl alcohol
• CAS NO: 79757-92-9
• Molecular Formula: C14H14O
• Molecular Weight: 198.26
• Mol File: 79757-92-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 119 °C
• Boiling Point: 351.1±21.0 °C(Predicted)
• Appearance: /
• Density: 1.072±0.06 g/cm3(Predicted)
• PKA: 14.37±0.10(Predicted)
• CAS DataBase Reference: (4'-METHYLBIPHENYL-4-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4'-METHYLBIPHENYL-4-YL)-METHANOL(79757-92-9)
• EPA Substance Registry System: (4'-METHYLBIPHENYL-4-YL)-METHANOL(79757-92-9)

Safety Data

• Hazardous Substances Data: 79757-92-9(Hazardous Substances Data)

Usage

General Description

(4'-Methylbiphenyl-4-yl)-methanol, also known as 4'-methyl-4-biphenylmethanol, is a chemical compound with the molecular formula C14H14O. It is a member of the biphenyl-4-yl-methanol class of compounds and exists as a white crystalline solid. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and other organic compounds. It is also used as a reagent in various chemical reactions and as an intermediate in the production of dyes and pigments. Additionally, (4'-Methylbiphenyl-4-yl)-methanol has potential applications in the field of organic electronic materials and can be used as a ligand in coordination chemistry.

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 106-38-7 para-bromotoluene 
• 59016-93-2 p-hydroxymethylphenylboronic acid 
• 14047-29-1 4-carboxyphenylboronic acid 
• 1122-91-4 4-bromo-benzaldehyde 
• 36393-42-7 4-(4-methylphenyl)benzaldehyde 
• 18282-51-4 4-iodo-benzyl alcohol 
• 5142-75-6 tri(p-tolyl)bismuth 
• 106-43-4 para-chlorotoluene 
• 720-73-0 4'-methyl-biphenyl-4-carboxylic acid 
• 873-76-7 para-Chlorobenzyl alcohol 
• 459-56-3 4-fluorobenzylic alcohol 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 613-33-2 (4,4'-dimethyl-1,1'-biphenyl) 

Downstream Products

• 49743-93-3 (4'-methyl[biphenyl]-4-yl)benzo[d]oxazole 

Relevant articles and documents

Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting additional efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal phenyl group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization.

Water-soluble palladacycles containing hydroxymethyl groups: Synthesis, crystal structures and use as catalysts for amination and Suzuki coupling of reactions

Two water-soluble monophosphine [PPh3 and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl(Sphos)]-palladacycles containing hydroxymethyl groups 2-3 were prepared by cyclopalladation and chloride bridge-splitting reactions. The complexes were characterized by elemental analysis, ESI-MS and NMR. In addition, single-crystal X-ray analysis reveals that they have one-dimensional lamellar structures involving intermolecular hydrogen bonds and π-π interactions. The use of these palladacycles as catalysts for amination and Suzuki coupling of aryl chlorides in water was investigated. Complex 3 was found to be very efficient for these coupling reactions. Additionally, it was also successfully used in Suzuki coupling of (hydroxymethyl)phenylboronic acid for the synthesis of substituted 2-N-heterocyclic biarylmethanols.

Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N -acylethanolamine acid amidase (NAAA) inhibitors

N-(2-Oxo-3-oxetanyl)carbamic acid esters have recently been reported to be noncompetitive inhibitors of the N-acylethanolamine acid amidase (NAAA) potentially useful for the treatment of pain and inflammation. In the present study, we further explored the