79781-00-3 Usage
Description
Bulaquine is a derivative of primaquine that was introduced in India in combination with
chloroquine as a treatment against malaria. The compound is prepared by condensation
of primaquine with 3-acetyl-y-butyrolactone in presence of a catalytic amount of base.
Bulaquine kills the latent tissue stage (hypnozoites) of the parasite Plasmodium vivax
accumulated in the liver and responsible for relapses. Its efficient anti-relapse activity was
demonstrated against sporozoite induced Plasmodium cynomolgi infection in rhesus
monkey. Bulaquine is safer than primaquine, the preceding candidate against malaria
relapse. Although it is stable at pH 7-8, bulaquine is hydrolyzed to primaquine under acidic
conditions.
Originator
CDRI (India)
Uses
Bulaquine is anti-malarial drug.
Brand name
Aablaquin
Check Digit Verification of cas no
The CAS Registry Mumber 79781-00-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,7,8 and 1 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 79781-00:
(7*7)+(6*9)+(5*7)+(4*8)+(3*1)+(2*0)+(1*0)=173
173 % 10 = 3
So 79781-00-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H27N3O3/c1-14(6-4-9-22-15(2)18-8-11-27-21(18)25)24-19-13-17(26-3)12-16-7-5-10-23-20(16)19/h5,7,10,12-14,22,24H,4,6,8-9,11H2,1-3H3/b18-15+
79781-00-3Relevant articles and documents
Reaction of α-Acetylbutyrolactone with Amines and Hydrazine
Bhat, Balkrishen,Seth, M.,Bhaduri, A. P.
, p. 703 - 705 (2007/10/02)
The ring-opening of α-acetylbutyrolactone with primary amines and hydrazine may follow either a 5-exo-tet or 5-exo-trig ring closure reaction.This aspect has been studied by identifying the reaction product of α-acetylbutyrolactone with primary amines.The structural assignments of these products have been made on the basis of chemical degradation and spectroscopic data.
