79944-37-9

Basic information

• Product Name: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane
• Synonyms: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane;L(+)-AMINODIOXEPANE ACETATE;TRANS-5-AMINO-6-HYDROXY-2,2-DIMETHYL-1,3-DIOXACYCLOHEPTANE;TRANS-6-AMINO-5-HYDROXY-2,2-DIMETHYL-1,3-DIOXEPANE ACETATE;(5R,6S)-6-AMINO-2,2-DIMETHYL-1,3-DIOXEPAN-5-OL HYDROCHLORIDE;trans-6-Amino-5-hydroxy-2,2-dimethyl-1,3-dioxepane;(5R, 6S)-6-Amino-2,2-dimethyl-1,3-dioxepan-5-ol;trans-(5RS,6SR)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol
• CAS NO: 79944-37-9
• Molecular Formula: C7H15NO3
• Molecular Weight: 161.2
• EINECS: 419-050-3
• Mol File: 79944-37-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 266.345 °C at 760 mmHg
• Flash Point: 114.881 °C
• Appearance: /
• Density: 1.08 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane(CAS DataBase Reference)
• NIST Chemistry Reference: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane(79944-37-9)
• EPA Substance Registry System: trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacyloheptane(79944-37-9)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 22-24/25-26-37
• Hazardous Substances Data: 79944-37-9(Hazardous Substances Data)

Usage

General Description

Trans-5-Amino-6-hydroxy-2,2-dimethyl-1,3-dioxacycloheptane is a chemical compound with a fairly complex and lengthy name. Its structure includes several functional groups: an amino group (NH2), which means it contains nitrogen; a hydroxy group (OH), which refers to the presence of oxygen; and two methyl groups (CH3), suggesting the presence of carbon and hydrogen. The part of its name, "1,3-dioxacycloheptane", implies that it's a seven-membered ring compound (cycloheptane) with two oxygen atoms incorporated within the ring (dioxacycloheptane). This chemical, like many others of similar complexity, is likely used in scientific research and in the production of specific pharmaceuticals, polymers, or advanced materials, though the sources don't specify its exact usage.

InChI:InChI=1/C7H15NO3/c1-7(2)10-3-5(8)6(9)4-11-7/h5-6,9H,3-4,8H2,1-2H3/t5-,6-/m0/s1

Upstream product

• 1010702-30-3 (5R,6S)-2,2-dimethyl-6-<(S)-1-phenylmethylamino>-1,3-dioxepan-5-ol 
• 57280-22-5 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]-octane 

Relevant articles and documents

Divergent approach to the synthesis of (-)-balanol heterocycle and cis-3-hydroxypipecolic acid based on chiral 2-aminoalkanol equivalent

Enantioselective synthesis of the hexahydroazepine core of (?)-balanol and formal synthesis of cis-3-hydroxypipecolic acid from a common intermediate have been accomplished by a divergent path. The common intermediate was accessed from a favorably protected enantiomerically pure 2-amino-1,3,4-butanetriol (ABT) equivalent via oxidation and Wittig olefination. The synthesis of (?)-balanol heterocycle featured tandem reduction/acetal-deprotection/γ-lactonization reaction and a one-pot azide reduction followed by seven membered aza-heterocycle formation while the route to cis-3-hydroxypipecolic acid highlighted the base induced piperidine ring formation and regioselective benzylidine-acetal cleavage.

Intermediates and synthesis of 2-amino-2-deoxytetritols

Novel methods are provided for synthesizing 2-amino-2-tetritol, by positive halogen addition to protected 1,4-dioxybutene-2 in the presence of a nitrile, resulting in addition of a halo functionality and the nitrile functionality across the double bond. Upon hydrolysis, the desired erythro-product can be obtained in stereochemically good yield.