79965-69-8

Basic information

• Product Name: 4-(2-chlorophenyl)-2-methyloxazole
• Synonyms: 4-(2-chlorophenyl)-2-methyloxazole
• CAS NO: 79965-69-8
• Molecular Weight: 193.633
• Mol File: 79965-69-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-chlorophenyl)-2-methyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-chlorophenyl)-2-methyloxazole(79965-69-8)
• EPA Substance Registry System: 4-(2-chlorophenyl)-2-methyloxazole(79965-69-8)

Safety Data

• Hazardous Substances Data: 79965-69-8(Hazardous Substances Data)

Upstream product

• 615-41-8 2-iodochlorobenzene 
• 1248075-48-0 2-(2-chlorophenyl)-2,2-difluoroacetic acid ethyl ester 
• 1380202-39-0 2-(2-chlorophenyl)-2,2-difluoroethanol 
• 75-05-8 acetonitrile 
• 60-35-5 acetamide 
• 5000-66-8 2-chlorophenacyl bromide 

Downstream Products

• 79965-78-9 4-(2-Chloro-phenyl)-2-methyl-5-nitro-oxazole 

Relevant articles and documents

Lewis acid-mediated defluorinative [3+2] cycloaddition/aromatization cascade of 2,2-difluoroethanol systems with nitriles

The properties of C?F bonds, including high thermal and chemical stability, make derivatization of organic fluorine-containing compounds by the activation of the C?F bond and subsequent functionalization quite challenging. We herein report a Lewis acid-mediated defluorinative cycloaddition/aromatization cascade of 2,2-difluoroethanols with nitriles as a novel synthetic method for the preparation of 2,4,5-trisubstituted oxazoles. This reaction, which involves cleavage of two C?F bonds and the consecutive formation of C?O and C?N bonds in a one-pot fashion, features a broad substrate scope and moderate to high reaction yields. Mechanistic studies revealed that the reaction is initiated by the Lewis acid-mediated ring closure of the 2,2-difluoroethanol to produce the fluoroepoxide intermediate. (Figure presented.).