80016-36-0Relevant articles and documents
Iso-maleimycin, a Constitutional Isomer of Maleimycin, from Streptomyces sp. QL37
Minnaard, Adriaan J.,Santiago, Isabel Nu?ez,Uiterweerd, Michiel T.,van Wezel, Gilles P.,van der Heul, Helga
, (2020/08/19)
Iso-maleimycin, a previously unknown constitutional isomer of the antibiotic maleimycin, has been detected in an extract of Streptomyces sp. QL37. Chemical synthesis of both maleimycin (20 % yield over seven steps) and iso-maleimycin, (15 % yield over six steps) allowed access to reference materials for identification. Gas Chromatography coupled Mass Spectrometry (GC-MS) analysis demonstrated that of the two isomers, only iso-maleimycin was present in the extract. This finding supports our hypothesis that iso-maleimycin is a biosynthetic intermediate of lugdunomycin. Iso-maleimycin displays low antibiotic activity, with a Minimum Inhibitory Concentration (MIC) value on both E. coli and B. subtilis of 250 μg/mL.
First synthesis of nitrosporeusines, alkaloids with multiple biological activities
Philkhana, Satish Chandra,Jachak, Gorakhnath R.,Gunjal, Vidya B.,Dhage, Nagsen M.,Bansode, Ajay H.,Reddy, D. Srinivasa
supporting information, p. 1252 - 1254 (2015/03/04)
Synthesis of nitrosporeusines A and B, thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus with exceptional biological activity is disclosed for the first time. In addition, we have prepared another biologically important natural product