800401-54-1

Basic information

• Product Name: 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid
• Synonyms: 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid;6-Chloro-1H-pyrrolo[3;6-Chloro-5-azaindole-2-carboxylic acid;1H-Pyrrolo[3,2-c]pyridine-2-carboxylic acid, 6-chloro-
• CAS NO: 800401-54-1
• Molecular Formula: C₈H₅ClN₂O₂
• Molecular Weight: 196.59
• Product Categories: CHIRAL CHEMICALS
• Mol File: 800401-54-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 500.883 °C at 760 mmHg
• Flash Point: 256.725 °C
• Appearance: /
• Density: 1.644
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.744
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.30±0.30(Predicted)
• CAS DataBase Reference: 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid(800401-54-1)
• EPA Substance Registry System: 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid(800401-54-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 800401-54-1(Hazardous Substances Data)

Usage

General Description

6-Chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid is a chemical compound with the molecular formula C9H6ClNO2. It is a bicyclic heteroaromatic compound containing a pyrrole ring fused to a pyridine ring. 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid has potential use in the pharmaceutical industry, particularly in the development of new drugs. Its structure and properties make it a promising candidate for the synthesis of bioactive compounds and pharmaceutical intermediates. Additionally, 6-Chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid has been studied for its potential anti-inflammatory and anti-cancer properties, and its structure is of interest for medicinal chemistry research.

InChI:InChI=1/C8H5ClN2O2/c9-7-2-1-4-5(11-7)3-6(10-4)8(12)13/h1-3,10H,(H,12,13)

Upstream product

• 800402-12-4 2-chloro-4-amino-5-iodopyridine 
• 1296201-72-3 2-chloro-5-((trimethylsilyl)ethynyl)pyridin-4-amine 
• 76-05-1 trifluoroacetic acid 
• 127-17-3 2-oxo-propionic acid 
• 14432-12-3 4-Amino-2-chloropyridine 

Downstream Products

• 1296203-15-0 C₁₆H₁₄ClN₃O₂ 
• 1296200-83-3 N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-2-carboxamide 

Relevant articles and documents

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I)

Rho kinase (ROCK) inhibitors are potential therapeutic agents to treat disorders such as hypertension, multiple sclerosis, cancers, and glaucoma. Here, we disclose the synthesis, optimization, biological evaluation of potent indole and 7-azaindole based ROCK inhibitors that have high potency on ROCK (IC 50 = 1 nM) with 740-fold selectivity over PKA (47). Moreover, 47 showed very good DMPK properties making it a good candidate for further development. Finally, docking studies with a homology model of ROCK-II were performed to rationalize the binding mode of these compounds and showed the compounds bound in both orientations to take advantage to H-bonds with Lys-121 of ROCK-II.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDES

Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.

PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE

Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, and as cardioprotectants.