80115-95-3

Basic information

• Product Name: N-ACETYL LEUKOTRIENE E4
• Synonyms: N-ACETYL LEUKOTRIENE E4;N-AC-LTE4;5S-HYDROXY-6R-(S-(N-ACETYL)CYSTEINYL)-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID;leukotriene E4, N-acetyl-;(5S,6R,7E,9E,11Z,14Z)-5-Hydroxy-6-[[(R)-2-acetylamino-2-carboxyethyl]thio]-7,9,11,14-icosatetraenoic acid;N-AcetylLTE4
• CAS NO: 80115-95-3
• Molecular Formula: C25H39NO6S
• Molecular Weight: 481.65
• Mol File: 80115-95-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 754.5 °C at 760 mmHg
• Flash Point: 410.1 °C
• Appearance: /
• Density: 1.137 g/cm³
• Vapor Pressure: 2.82E-26mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: −20°C
• CAS DataBase Reference: N-ACETYL LEUKOTRIENE E4(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYL LEUKOTRIENE E4(80115-95-3)
• EPA Substance Registry System: N-ACETYL LEUKOTRIENE E4(80115-95-3)

Safety Data

• Hazard Codes: F,T
• Statements: 11
• Safety Statements: 7-16-23-45
• RIDADR: UN 1230 3/PG 2
• Hazardous Substances Data: 80115-95-3(Hazardous Substances Data)

Usage

Description

N-ACETYL LEUKOTRIENE E4, also known as N-acetyl LTE4, is the major inactive metabolite of Leukotriene E4 (LTE4) found in bile. It is 100 times less potent than Leukotriene C4 (LTC4) as a vasoconstricting agent. In humans, the urinary excretion of N-acetyl LTE4 is considerably less than that of LTE4.

Uses

Used in Pharmaceutical Research:
N-ACETYL LEUKOTRIENE E4 is used as a research compound for studying the metabolism and biological activity of leukotrienes, which are important mediators of inflammation and other physiological processes.
Used in Drug Development:
N-ACETYL LEUKOTRIENE E4 is used as a reference standard in the development and validation of analytical methods for the quantification of leukotrienes in biological samples, such as urine.
Used in Clinical Diagnostics:
N-ACETYL LEUKOTRIENE E4 is used as a biomarker in clinical diagnostics to assess the activity of leukotriene pathways in various diseases, including asthma and inflammatory disorders.
Used in Toxicology Studies:
N-ACETYL LEUKOTRIENE E4 is used as a control compound in toxicology studies to evaluate the safety and efficacy of drugs targeting leukotriene pathways.
Used in Basic Research:
N-ACETYL LEUKOTRIENE E4 is used as a tool compound in basic research to investigate the molecular mechanisms underlying leukotriene signaling and their role in cellular processes.

InChI:InChI=1/C25H39NO6S/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-23(22(28)16-15-18-24(29)30)33-19-21(25(31)32)26-20(2)27/h7-8,10-14,17,21-23,28H,3-6,9,15-16,18-19H2,1-2H3,(H,26,27)(H,29,30)(H,31,32)/b8-7+,11-10+,13-12+,17-14+/t21?,22-,23+/m0/s1