80232-86-6

Basic information

• Product Name: 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole
• Synonyms: 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole
• CAS NO: 80232-86-6
• Molecular Weight: 215.319
• Mol File: 80232-86-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole(80232-86-6)
• EPA Substance Registry System: 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole(80232-86-6)

Safety Data

• Hazardous Substances Data: 80232-86-6(Hazardous Substances Data)

Upstream product

• 108-94-1 cyclohexanone 
• 100-52-7 benzaldehyde 
• 137858-58-3 2-benzamidocyclohexanone 
• 1170696-56-6 C₁₃H₁₄BrNS 
• 2227-79-4 benzenecarbothioamide 
• 122687-60-9 2-phenyl-3-thia-1-azaspiro[4,4]non-1-ene-4-thione 
• 124292-93-9 4-Isopropoxy-2-phenyl-2-trifluoromethyl-2H-oxazol-5-one 
• 124292-86-0 2-isopropoxy-1-aza-4-oxaspiro[4.5]dec-1-en-3-one 
• 51595-54-1 1-Chlor-7-oxa-bicyclo<4.1.0>heptan 
• 106270-39-7 2-phenyl-2,4,5,6,7,7a-hexahydro-benzothiazole 
• 42904-05-2 α-mercaptocyclohexanone 

Downstream Products

• 883-93-2 2-Phenylbenzothiazole 

Relevant articles and documents

Four-component thiazole formation from simple chemicals under metal-free conditions

Multi-component reactions for the synthesis of polysubstituted thiazoles from simple chemicals are described. Under metal-free reaction conditions, cheap and easily available ketones, aldehydes, ammonium salt, and elemental sulfur are self-assembled to provide entries to three thiazoles in moderate to good yield with a range of functionalities tolerated.

Intramolecular nucleophilic substitution at an sp2 carbon: synthesis of substituted thiazoles and imidazole-2-thiones

The nucleophilic substitution reactions of vinylic bromides with intramolecular thioamide or thiourea moieties proceed to give a series of substituted thiazoles and imidazole-2-thiones.

1,3-dipolar cycloadditions with 1-alkoxy-substituted nitrile ylides

Thermolysis of 4-alkoxy-1,3-oxazol-5(2H)-ones (2) (X = O) leads to reactive nitrile ylides (1) bearing an alkoxy substituent at the nitrile C-atom. These intermediates can be trapped by C,C-, C,O-, C,N-, and C,S-dipolarophiles, yielding 5-membered heterocycles via 1,3-dipolar cycloaddition. In the case of 1,3-thiazole-5(4H)-thiones (11) as dipolarophiles, two regioisomeric cycloadducts were obtained. The results of the cycloadditions are discussed with respect to the influence of the alkoxy substituent on the structure of the nitrile ylide.