80615-54-9Relevant articles and documents
p38 kinase inhibitors for the treatment of arthritis and osteoporosis: Thienyl, furyl, and pyrrolyl ureas
Redman, Aniko M,Johnson, Jeffrey S.,Dally, Robert,Swartz, Steve,Wild, Hanno,Paulsen, Holger,Caringal, Yolanda,Gunn, David,Renick, Joel,Osterhout, Martin,Kingery-Wood, Jill,Smith, Roger A.,Lee, Wendy,Dumas, Jacques,Wilhelm, Scott M.,Housley, Timothy J.,Bhargava, Ajay,Ranges, Gerald E.,Shrikhande, Alka,Young, Deborah,Bombara, Michael,Scott, William J.
, p. 9 - 12 (2007/10/03)
Inhibitors of the MAP kinase p38 are potentially useful for the treatment for osteoporosis, arthritis, and other inflammatory diseases. A series of thienyl, furyl, and pyrrolyl ureas has been identified as potent p38 inhibitors, displaying in vitro activity in the nanomolar range. (C) 2000 Elsevier Science Ltd.
Potent selective thienoxazinone inhibitors of herpes proteases
Jarvest, Richard L.,Connor, Susan C.,Gorniak, Joselina G.,Jennings, L. John,Serafinowska, Halina T.,West, Andrew
, p. 1733 - 1738 (2007/10/03)
Thieno[3,2-d]oxazinones are potent, selective, mechanism-based inhibitors of the herpes proteases with good aqueous stability. Specificity between the HSV and CMV proteases varies across the series: compounds 14b and 14c are submicromolar HSV protease inhibitors with modest CMV protease inhibition, 14g is a selective CMV protease inhibitor, and 32 inhibits both enzymes with an IC50 of about 1 μM.
A new synthesis of biotin
Rossy,Vogel,Hoffman,et al.
, p. 3493 - 3496 (2007/10/02)
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