80697-91-2

Basic information

• Product Name: (4R,5S)-(+)-4-methyl-3-(1'-oxobutyl)-5-phenyloxazolidin-2-one
• Synonyms: (4R,5S)-(+)-4-methyl-3-(1'-oxobutyl)-5-phenyloxazolidin-2-one
• CAS NO: 80697-91-2
• Molecular Weight: 247.294
• Mol File: 80697-91-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (4R,5S)-(+)-4-methyl-3-(1'-oxobutyl)-5-phenyloxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-(+)-4-methyl-3-(1'-oxobutyl)-5-phenyloxazolidin-2-one(80697-91-2)
• EPA Substance Registry System: (4R,5S)-(+)-4-methyl-3-(1'-oxobutyl)-5-phenyloxazolidin-2-one(80697-91-2)

Safety Data

• Hazardous Substances Data: 80697-91-2(Hazardous Substances Data)

Upstream product

• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 
• 141-75-3 butyryl chloride 
• 492-39-7 (1S,2S)-2-amino-1-phenylpropanol 
• 107645-17-0 (3-Methoxymethoxy-phenyl)-acetaldehyde 
• 107645-16-9 C₂₂H₃₄BNO₃ 
• 106-31-0 butanoic acid anhydride 
• 37577-28-9 (1S,2R)-(+)-norphedrine 

Downstream Products

• 121074-25-7 (4R,5S)-3-[(2S)-1-oxo-2-ethyl-4-pentenyl]-4-methyl-5-phenyl-2-oxazolidinone 
• 1104899-97-9 C₁₉H₂₅NO₄ 
• 107691-87-2 (2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(7'-t-butyldimethylsilyloxy-2'-ethyl-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one 
• 130514-52-2 (2'R,2''S,3''S,4R,5S,5''R)-(+)-<2'-(3'',5''-dimethyl-6''-oxotetrahydropyran-2''-yl)-1'-oxobutyl>-4-methyl-5-phenyloxazolidin-2-one 
• 130514-51-1 (4R,5S)-3-[(R)-2-((2S,3S,5R)-6-Hydroxy-3,5-dimethyl-tetrahydro-pyran-2-yl)-butyryl]-4-methyl-5-phenyl-oxazolidin-2-one 
• 107691-86-1 (2'R,3'S,4R,4'S,5S,6'R)-(-)-3-(2'-ethyl-7'-hydroxy-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyheptyl)-4-methyl-5-phenyloxazolidin-2-one 
• 107691-85-0 (2'R,3'S,4R,4'S,5S)-(-)-3-(2'-ethyl-4',6'-dimethyl-1'-oxo-3'-trimethylsilyloxyhept-6'-enyl)-4-methyl-5-phenyloxazolidin-2-one 
• 130514-50-0 (2'R,3'S,4R,4'S,5S,6'R)-(+)-3-(2'-ethyl-3',7'-dihydroxy-4',6'-dimethyl-1'-oxoheptyl)-4-methyl-5-phenyloxazolidin-2-one 
• 219507-06-9 methyl (2S)-4-{(2S)-2-[((4R,5S)-4-methyl-5-phenyl-2-oxazolidinone-3-yl)carbonyl]butyl-(R,S)-sulfonimidoyl}-2-(N-4-nitrobenzyloxycarbonylamino)butanoate 
• 219507-03-6 (S)-4-[(S)-2-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidine-3-carbonyl)-butane-1-sulfinyl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid methyl ester 
• 219507-00-3 (S)-4-[(S)-2-((4R,5S)-4-Methyl-2-oxo-5-phenyl-oxazolidine-3-carbonyl)-butylsulfanyl]-2-(4-nitro-benzyloxycarbonylamino)-butyric acid methyl ester 
• 219506-93-1 Methanesulfonic acid (R)-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidine-3-carbonyl)-butyl ester 
• 219506-97-5 (4R,5S)-3-((S)-2-Iodomethyl-butyryl)-4-methyl-5-phenyl-oxazolidin-2-one 

Relevant articles and documents

Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones

Identifying the targets of bioactive small molecules is a challenging endeavor for which no general solution currently exists. Classical affinity purification experiments suffer from the need to functionalise a bioactive compound and link it to a solid support, which may interfere with target binding. A modern mass spectrometry-based proteomics technique that has partially circumvented this problem is thermal proteome profiling (TPP), which determines the effect of an unmodified small molecule on the thermal stability of the whole proteome simultaneously. Here, we use TPP to identify the mode-of-action of a newly-discovered autophagy inhibitor based on oxazolidinones often employed as chiral auxiliaries. Surprisingly, a significant portion of all ribosomal proteins were found to be destabilized by the inhibitor, highlighting the utility of this technology for determining a challenging mode-of-action.

Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases

Certain 2H-pyran-2-ones are useful for treating benign prostatic hypertrophy or hyperplasia, prostatic cancer, alopecia, hirsutism, acne vulgaris and seborrhea.

A practical method for N-acylation of bornane-2,10-sultam and 2-oxazolidinones

The N-trimethylsilyl derivatives of (+)-bornane-2,10-sultam (10,10-dimethyl-5-thia-4-azatricyclo[5.2.1.03,7]decane 5,5-dioxide) and (R)-4-benzyl-2-oxazolidinone and 4-methyl-5-phenyl-2-oxazolidinone react with acid chlorides in refluxing benzen