80751-65-1 Usage
Description
(+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE, also known as Chloro-APB hydrobromide, is a chemical compound that acts as a pharmacological tool for studying the effects of dopamine receptor stimulation. It is characterized by its complex structure, which includes a benzazepine core, a chloro substituent, and hydroxy and allyl groups, as well as a hydrobromide counterion. (+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE is valuable for investigating the role of D1 dopamine receptors in various physiological and pathological processes.
Uses
Used in Neuropharmacological Research:
Chloro-APB hydrobromide is used as a pharmacological agent for stimulating D1 dopamine receptors. It is particularly useful for studying the influence of D1 receptor activation on locomotor response in specific neuronal populations, such as fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice. This application helps researchers to better understand the role of D1 dopamine receptors in motor control and related neurological disorders.
Used in Drug Development:
Chloro-APB hydrobromide can also be employed in the development of new drugs targeting the D1 dopamine receptor. By studying the effects of this compound on receptor activation and downstream signaling pathways, researchers can gain insights into the design of more selective and potent D1 receptor agonists or antagonists for the treatment of various neurological and psychiatric conditions, such as Parkinson's disease, schizophrenia, and addiction.
Used in Cellular and Molecular Biology:
In addition to its applications in neuropharmacology and drug development, Chloro-APB hydrobromide can be used as a research tool in cellular and molecular biology. For example, it can be employed to investigate the mechanisms of D1 receptor signaling, gene expression, and cellular function in different cell types and model organisms. This can provide valuable information on the role of D1 dopamine receptors in cellular processes and contribute to the development of novel therapeutic strategies.
Biochem/physiol Actions
Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist. D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.
Check Digit Verification of cas no
The CAS Registry Mumber 80751-65-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,7,5 and 1 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 80751-65:
(7*8)+(6*0)+(5*7)+(4*5)+(3*1)+(2*6)+(1*5)=131
131 % 10 = 1
So 80751-65-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
80751-65-1Relevant articles and documents
Ultrasound in organic syntheses. 19. Further studies on the conjugate additions to electron deficient olefins in aqeuous media
Dupuy,Petrier,Sarandeses,Luche
, p. 643 - 651 (2007/10/02)
Alkyl halides add smoothly to a variety of olefinic bonds conjugated with electron withdrawing groups, in the presence of zinc-copper couple. Sonication enhances the efficiency of the process, which takes place in aqeuous media following, most probably, a radical pathway.
