80937-31-1

Basic information

• Product Name: Flosulide
• Synonyms: Flosulide;CGP-28238;CGP-28328;N-[[6-(2,4-Difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden]-5-yl]methanesulfonamide;N-[1-Oxo-6-(2,4-difluorophenoxy)indan-5-yl]methanesulfonamide;ZK-38997
• CAS NO: 80937-31-1
• Molecular Formula: C₁₆H₁₃F₂NO₄S
• Molecular Weight: 353.344
• Mol File: 80937-31-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 156 °C(Solv: ethanol (64-17-5))
• Boiling Point: 446.9°C at 760 mmHg
• Flash Point: 224.1°C
• Appearance: /
• Density: 1.506g/cm³
• Vapor Pressure: 3.51E-08mmHg at 25°C
• Refractive Index: 1.62
• PKA: 6.95±0.20(Predicted)
• CAS DataBase Reference: Flosulide(CAS DataBase Reference)
• NIST Chemistry Reference: Flosulide(80937-31-1)
• EPA Substance Registry System: Flosulide(80937-31-1)

Safety Data

• Hazardous Substances Data: 80937-31-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H13F2NO4S/c1-24(21,22)19-13-6-9-2-4-14(20)11(9)8-16(13)23-15-5-3-10(17)7-12(15)18/h3,5-8,19H,2,4H2,1H3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 82505-55-3 5-amino-6-(2,4-difluorophenoxy)-1-indanone 
• 1027942-72-8 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid chloride 
• 367-27-1 2,4-difluorophenol 
• 173282-22-9 4-(2,4-difluorophenoxy)-3-nitrobenzaldehyde 
• 173282-24-1 ethyl 3-amino-4-(2,4-difluorophenoxy)phenylpropionate 
• 173282-26-3 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid 
• 173282-25-2 ethyl 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionate 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 82505-48-4 6-(2,4-Difluoro-phenoxy)-5-nitro-indan-1-one 
• 82505-51-9 5-acetylamino-6-(2,4-difluorophenoxy)-1-indanone 
• 81614-79-1 6-(2,4-difluorophenoxy)-5-indanylamine 

Downstream Products

• 88040-98-6 N-[6-(2,4-difluorophenoxy)-1-methylamino-5-indanyl]methanesulfonamide, hydrochloride 
• 83498-50-4 N-[6-(2,4-difluorophenoxy)-1-hydroxy-5-indanyl]methanesulfonamide 

Relevant articles and documents

Method for the treatment and prevention of cachexia

Cachexia, including anorexia and other forms of weight loss, is a frequent complication of acute and chronic infections, and result from induction of cytokines, prostaglandins, and other inflammatory mediators that are critical for pathogen elimination. The present invention includes methods for the treatment or prevention of cachexic conditions while maintaining the production of factors essential for infection control through the administration of an effective amount of a cyclooxygenase-2 selective inhibiting compound.

Improved synthesis of a selective COX-2 inhibitor, 6-(2,4-difluorophenoxy)-5-methane-sulfonamidoindan-1-one (flosulide)

An improved synthesis of Flosulide (1), a selective COX-2 inhibitor, from the cheap and commercially available 4-chloro-3-nitrobenzaldehyde (2) by using an intramolecular Friedel-Crafts reaction of 4-(2,4-difluorophenoxy)-3-methanesulfonamidophenylpropionic acid (7) as the key step is reported.