81004-54-8 Usage
Chemical structure
1,N(6)-etheno-2'-deoxyadenosine 5'-triphosphate is a modified form of deoxyadenosine triphosphate (dATP) with an etheno group attached to the N(6) position of the adenine base.
Induction
The modification can be induced by exposure to certain chemical and physical agents.
DNA adducts
The presence of 1,N(6)-etheno-2'-deoxyadenosine 5'-triphosphate in the cell can lead to the formation of DNA adducts.
Genetic mutations
The formation of DNA adducts can cause genetic mutations.
Carcinogenesis
The genetic mutations can potentially contribute to carcinogenesis.
Disruption of DNA replication and repair
The presence of 1,N(6)-etheno-2'-deoxyadenosine 5'-triphosphate in the cell can disrupt normal DNA replication and repair processes.
Genomic instability
The disruption of DNA replication and repair processes can lead to genomic instability.
Mutagenic and genotoxic compound
1,N(6)-etheno-2'-deoxyadenosine 5'-triphosphate is considered a mutagenic and genotoxic compound.
Cellular integrity and function
The compound can have harmful effects on cellular integrity and function.
Substrate for DNA polymerases
Studies have shown that this modified nucleotide can serve as a substrate for DNA polymerases.
Incorporation into DNA
The modified nucleotide can be incorporated into DNA.
Potential for mutagenic events
The incorporation of the modified nucleotide into DNA can lead to the potential for mutagenic events.
Check Digit Verification of cas no
The CAS Registry Mumber 81004-54-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,0,0 and 4 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 81004-54:
(7*8)+(6*1)+(5*0)+(4*0)+(3*4)+(2*5)+(1*4)=88
88 % 10 = 8
So 81004-54-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N5O12P3/c18-7-3-9(17-6-14-10-11-13-1-2-16(11)5-15-12(10)17)27-8(7)4-26-31(22,23)29-32(24,25)28-30(19,20)21/h1-2,5-9,18H,3-4H2,(H,22,23)(H,24,25)(H2,19,20,21)/t7-,8+,9+/m0/s1