81014-98-4

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 4-(4-hydroxyphenyl)-2,6-dimethyl-, diethyl ester
• CAS NO: 81014-98-4
• Molecular Formula: C19H21NO5
• Molecular Weight: 343.379
• Mol File: 81014-98-4.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 4-(4-hydroxyphenyl)-2,6-dimethyl-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 4-(4-hydroxyphenyl)-2,6-dimethyl-, diethyl ester(81014-98-4)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 4-(4-hydroxyphenyl)-2,6-dimethyl-, diethyl ester(81014-98-4)

Safety Data

• Hazardous Substances Data: 81014-98-4(Hazardous Substances Data)

Upstream product

• 10354-30-0 4-(4-hydroxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 631-61-8 ammonium acetate 
• 141-97-9 ethyl acetoacetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1479-24-9 ethyl 2-fluorobenzoylacetate 
• 5396-89-4 benzyl acetoacetate 
• 1118-84-9 allyl acetoacetate 
• 1694-31-1 tert-butyl acetoacetate 
• 838-57-3 ethyl 4-nitrobenzoylacetate 
• 105-45-3 acetoacetic acid methyl ester 
• 126-81-8 dimedone 

Relevant articles and documents

Silica-supported ceric ammonium nitrate (CAN): a simple, mild and solid-supported reagent for quickest oxidative aromatization of Hantzsch 1,4-dihydropyridines

An efficient and environmentally benign methodology for the oxidative aromatization of 1,4-dihydropyridines to their corresponding pyridine derivatives is developed. The oxidative aromatization of 1,4-dihydropyridines was explored using silica-supported ceric ammonium nitrate as catalyst in CH3CN with or without sonication at room temperature. This supported catalyst acts as a more efficient oxidising reagent and offers several advantages over other reported reagents in terms of reaction time and yields. The supported reagent is found to be more efficient and selective when compared with its unsupported form. The Belousov–Zhabotinskii reaction was not observed in present reaction. The dealkylation observed in case of 4-n-alkyl/n-alkenyl with other oxidising agents is also not observed in the present case.

One-pot synthesis of 3-hydroxy-2-oxindole-pyridine hybrids via Hantzsch ester formation, oxidative aromatization and sp3 C–H functionalization using FeWO4 nanoparticles as recyclable heterogeneous catalyst

Synthesis of poly-substituted 3-hydroxy-2-oxindole-pyridine hybrids is reported via sp3 C–H bond functionalization as key steps using FeWO4 nanoparticles as reusable heterogeneous catalyst. Formation of Hantzsch ester (DHP) followed by aromatization, and sp3 C–H bond functionalization was achieved using FeWO4 nanoparticles (20 mol%) at 80 °C. Temperature dependent reactivity was observed for mono aldol (at 80 °C) and bis aldol (at 120 °C) products. The catalyst was regenerated and reused up to 6 cycles without losing catalytic activity. The FeWO4 nanoparticles were also used for oxidative aromatization of different DHP derivatives and for the sp3 C–H functionalization of 2-methyl pyridine.

A new oxidation system for the oxidation of Hantzsch-1,4-dihydropyridines and polyhydroquinoline derivatives under mild conditions

A new oxidation system (Na2S2O4/TBHP) to prepare pyridine derivatives has been developed by the oxidation of 1,4-dihydropyridine derivatives and polyhydroquinoline derivatives in good to excellent yields. The procedures of the reaction were green, convenient, mild and easy work-up.