81069-02-5

Basic information

• Product Name: 3,3'-Dithiobis(sulfosuccinimidylpropionate)
• Synonyms: 3,3Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester;3,3'-Dithiobis(sulfosuccinimidylpropionate);3,3’-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester 90%;DTSSP 3,3'-Dithiobis(sulfosucciniMidylpropionate);3,3`-Dithiobis(sulfosucciniMidylpropionate)(DTSSP(Sulfo-DSP));DTSSP Crosslinker
• CAS NO: 81069-02-5
• Molecular Formula: C14H14N2Na2O14S4
• Molecular Weight: 564.54
• Product Categories: Cross Linking Reagents;Homobifunctional Crosslinker
• Mol File: 81069-02-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.94
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• PKA: -0.34±0.20(Predicted)
• CAS DataBase Reference: 3,3'-Dithiobis(sulfosuccinimidylpropionate)(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3'-Dithiobis(sulfosuccinimidylpropionate)(81069-02-5)
• EPA Substance Registry System: 3,3'-Dithiobis(sulfosuccinimidylpropionate)(81069-02-5)

Safety Data

• Safety Statements: 26-36
• Hazardous Substances Data: 81069-02-5(Hazardous Substances Data)

Usage

Chemical Properties

12.0

Uses

Different sources of media describe the Uses of 81069-02-5 differently. You can refer to the following data:
1. sulfhydryl reactive cleavable heterobifunctional cross-linking reagent, pyridine-2-thione release can be monitored at 343 nm after reactions with sulfhydryl groups
2. It is a water-soluble, thiol cleavable, homobifunctional and amine-reactive crosslinking agent.

General Description

DTSSP is 3,3′-Dithiobis(sulfosuccinimidylpropionate), which contains an amine-reactive N-hydroxysulfosuccinimide (sulfo-NHS) ester at each end of an 8-carbon spacer arm. Sulfo-NHS esters react with primary amines at pH 7-9 to form stable amide bonds, along with release of the N-hydroxysulfosuccinimide leaving group. Proteins, including antibodies, generally have several primary amines in the side chain of lysine (K) residues and the N-terminus of each polypeptide that are available as targets for sulfo-NHS-ester crosslinking reagents. DSS, the non-sulfonated analog of DTSSP is also available for applications that require a membrane-permeable crosslinker.

Relevant articles and documents

DLL3-TARGETING MULTISPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF

The disclosure provides multispecific antigen-binding molecules that comprise a first antigen-binding moiety and a second antigen-binding moiety, each of which is capable of binding to CD3 and CD137, but does not bind to CD3 and CD137 at the same time; and a third antigen-binding moiety that is capable of binding to DLL3, preferably human DLL3, which induce T-cell dependent cytotoxity more efficiently whilst circumventing adverse toxicity concerns or side effects that other multispecific antigen-binding molecules may have. The present invention provides multispecific antigen-binding molecules and pharmaceutical compositions that can treat various cancers, especially those associated with DLL3, by comprising the antigen-binding molecule as an active ingredient.