81099-86-7

Basic information

• Product Name: 7-Chloro-4-(4-hydroxyanilino)quinoline
• Synonyms: 7-Chloro-4-(4-hydroxyanilino)quinoline;7-chloro-4-p-hydroxyanilinoquinoline;NSC 12488;NSC 130792;p-[(7-Chloro-4-quinolyl)aMino]phenol;AModiaquine IMpurity C
• CAS NO: 81099-86-7
• Molecular Formula: C₁₅H₁₁ClN₂O
• Molecular Weight: 270.71364
• Product Categories: Amines;Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 81099-86-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 439.1°Cat760mmHg
• Flash Point: 219.4°C
• Appearance: /
• Density: 1.401g/cm³
• Vapor Pressure: 2.54E-08mmHg at 25°C
• Refractive Index: 1.745
• CAS DataBase Reference: 7-Chloro-4-(4-hydroxyanilino)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Chloro-4-(4-hydroxyanilino)quinoline(81099-86-7)
• EPA Substance Registry System: 7-Chloro-4-(4-hydroxyanilino)quinoline(81099-86-7)

Safety Data

• Hazardous Substances Data: 81099-86-7(Hazardous Substances Data)

Usage

Uses

An impurity of Amodiaquine (A634200) with antimalarial activity.

InChI:InChI=1/C15H11ClN2O/c16-10-1-6-13-14(7-8-17-15(13)9-10)18-11-2-4-12(19)5-3-11/h1-9,19H,(H,17,18)

Upstream product

• 21617-15-2 7-chloro-1,2,3,4-tetrahydroquinolin-4-one 
• 100-02-7 4-nitro-phenol 
• 123-30-8 4-amino-phenol 
• 86-98-6 4,7-dichloroquinoline 
• 3648-96-2 4-amino-phenol; sulfate 
• 51-78-5 p-aminophenol hydrochloride 
• 6059-31-0 7-chloro-N-(4-methoxyphenyl)quinolin-4-amine 
• 26413-49-0 1-acetyl-7-chloro-2,3-dihydro-1H-quinolin-4-one 
• 5382-15-0 ethyl 3-((4-methoxyphenyl)amino)-3-oxopropanoate 
• 5507-39-1 2-(3-chloro-anilinomethylene)-N-(4-methoxy-phenyl)-malonamic acid ethyl ester 
• 5570-84-3 7-chloro-4-(4-methoxy-anilino)-quinoline-3-carboxylic acid 
• 104-94-9 4-methoxy-aniline 
• 102021-96-5 4-p-anisidino-7-chloro-quinoline-3-carboxylic acid ethyl ester 

Downstream Products

• 1312291-20-5 4-[(7-chloroquinolin-4-yl)amino]-2,6-bis(4-methylpiperazin-1-ylmethyl)phenol 
• 5201-88-7 4-<3,5-bis<(N-pyrrolidinyl)methyl>-4-hydroxyanilino>-7-chloroquinoline 
• 1312291-19-2 4-[(7-chloroquinolin-4-yl)amino]-2,6-bis(morpholin-4-ylmethyl)phenol 
• 59219-61-3 4-(7'-chloroquinolin-4'-ylamino)-2,6-bis(diethylaminomethyl)phenol 
• 132400-18-1 4-(7-chloro-quinolin-4-ylamino)-2-dibutylaminomethyl-phenol 
• 132400-21-6 4-(7-chloro-quinolin-4-ylamino)-2-(morpholin-4-ylmethyl)phenol 
• 132400-20-5 4-(7-chloro-[4]quinolylamino)-2-piperidinomethyl-phenol 

Relevant articles and documents

Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms

The ligand-activated transcription factor nuclear receptor related-1 (Nurr1) exhibits great potential for neurodegenerative disease treatment, but potent Nurr1 modulators to further probe and validate the nuclear receptor as a therapeutic target are lacki

Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters

New 4-aminoquinoline-derived esters containing the redox-active ferrocene group brought in by either ferrocenyformic or 4-ferrocenylbutanoic acids were synthesized and tested in vitro for their antiplasmodial activity. The results revealed that only ester

Process for the preparation of 4-amino-chloroquinolines

4-Amino-chloroquinolines of the formula: STR1 in which R1 represents a hydrogen atom or an alkyl radical (1 to 5 carbon atoms), and R2 represents an alkyl radical (1 to 5 carbon atoms) optionally substituted by a dialkylamino group, or a phenyl radical optionally substituted by one or more carboxy and hydroxy radicals and alkyl radicals (1 to 4 carbon atoms) optionally substituted by a dialkylamino group, are prepared by the condensation of an amine of the formula: STR2 with a chloro-1,2,3,4-tetrahydroquinolin-4-one of the formula: STR3 with aromatization of the tetrahydroquinoline, the reaction being carried out in the presence of a ruthenium based catalyst on a support. The 4-amino-chloroquinoline products are useful as pharmaceuticals.