811810-67-0

Basic information

• Product Name: 5-CHLORO-7-NITRO-2(3H)-BENZOXAZOLONE
• Synonyms: 5-CHLORO-7-NITRO-2(3H)-BENZOXAZOLONE;5-CHLORO-7-NITROBENZO[D]OXAZOL-2(3H)-ONE;5-Chloro-2,3-dihydro-7-nitro-2-oxo-1,3-benzoxazole;5-Chloro-7-nitro-1,3-benzoxazol-2(3H)-one;5-Chloro-7-nitro-2,3-dihydro-1,3-benzoxazol-2-one;5-Chloro-7-nitro-3H-benzooxazol-2-one
• CAS NO: 811810-67-0
• Molecular Formula: C₇H₃ClN₂O₄
• Molecular Weight: 214.56272
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 811810-67-0.mol
• Article Data: 9

Chemical Properties

• Appearance: off-white solid
• Density: 1.704 g/cm³
• Refractive Index: 1.646
• Solubility: Ethanol, Methanol
• CAS DataBase Reference: 5-CHLORO-7-NITRO-2(3H)-BENZOXAZOLONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-7-NITRO-2(3H)-BENZOXAZOLONE(811810-67-0)
• EPA Substance Registry System: 5-CHLORO-7-NITRO-2(3H)-BENZOXAZOLONE(811810-67-0)

Safety Data

• Hazardous Substances Data: 811810-67-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 811810-67-0 differently. You can refer to the following data:
1. As an intermediate in the synthesis of Bifeprunox, 5-Chloro-7-nitro-2(3H)-benzoxazolone is used as an antipsychotic compound.
2. An intermediate in the synthesis of Bifeprunox, which is used as an antipsychotic compound.

InChI:InChI=1/C7H3ClN2O4/c8-3-1-4-6(14-7(11)9-4)5(2-3)10(12)13/h1-2H,(H,9,11)

Upstream product

• 75-44-5 phosgene 
• 6358-08-3 4-chloro-6-nitro-2-aminophenol 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1338064-96-2 2-(4-(trifluoromethyl)phenyl)-N-(2,3-dihydro-2-oxobenzo[d]oxazol-7-yl)acetamide 
• 1338064-74-6 1-(4-(trifluoromethyl)-2-(piperidin-1-yl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-7-yl)urea 
• 1338064-73-5 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-7-yl)urea 
• 1338064-72-4 1-(4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-7-yl)urea 
• 81282-60-2 7-aminobenzo[d]oxazol-2(3H)-one 
• 889884-60-0 C₇H₅ClN₂O₂ 

Relevant articles and documents

Modified benzoxazolone derivative as 18-kDa TSPO ligand

We have synthesized six new congeners of acetamidobenzoxazolone for Translocator Protein [18 kDa, TSPO] imaging. The best in vitro binding affinity (10.8?±?1.2?nm) for TSPO was found for N-methyl-2-(5-(naphthalen-1-yl)-2-oxobenzo[d]oxazol-3(2H)-yl)-N-phen

TRPV1 vanilloid receptor antagonists with a bicyclic portion

The invention discloses compounds of formula I wherein Y s selected from a group of formula and W, Q, n, R1, R2, R3, U1-U5 have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1. 1.

SPIROHYDANTOIN ARYL CGRP RECEPTOR ANTAGONISTS

Compounds of formula (I); (wherein variables A1, A2. A3, A4, A5, A6, A7, B3 E1, E2, E3, E4, E5, G1, G2 and R.6 are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.