81323-56-0Relevant articles and documents
Enantioselective synthesis of 3-hydroxypiperidin-2-ones
Gibbs, Gary,Hateley, Martin J.,McLaren, Lee,Welham, Matthew,Willis, Christine L.
, p. 1069 - 1072 (2007/10/03)
An efficient synthesis of (S)- and (R)-3-hydroxypiperidin-2-ones from methyl 5-nitro-2-oxopentanoate is described. A one-pot enzyme catalysed hydrolysis of the ester and reduction of the ketone gave enantiopure 2- hydroxy-5-nitropentanoic acids which on esterification, catalytic hydrogenation over a platinum(IV) oxide catalyst and intramolecular: cyclisation gave the target compounds in 93% overall yield and >99% ee.