813462-83-8

Basic information

• Product Name: 1H-Imidazole-4-carbonitrile, 5-acetyl-
• Synonyms: 1H-Imidazole-4-carbonitrile, 5-acetyl-
• CAS NO: 813462-83-8
• Molecular Formula: C6H5N3O
• Molecular Weight: 135.12
• Mol File: 813462-83-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Imidazole-4-carbonitrile, 5-acetyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Imidazole-4-carbonitrile, 5-acetyl-(813462-83-8)
• EPA Substance Registry System: 1H-Imidazole-4-carbonitrile, 5-acetyl-(813462-83-8)

Safety Data

• Hazardous Substances Data: 813462-83-8(Hazardous Substances Data)

Upstream product

• 1122-28-7 4,5-dicyano-1H-imidazole 
• 75-16-1 methylmagnesium bromide 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 813462-82-7 4-amino-7-methyl-3H-imidazo[4,5-d]pyridazine 

Relevant articles and documents

Synthesis of 2-bromo-7-methyl-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and 3-alkyl-2-bromo-3,5-dihydro-imidazo[4,5-d]pyridazin-4-one and their selective elaboration

Two synthetic routes to the versatile 3,5-dihydro-imidazo[4,5-d]pyridazin-4-ones 2 and 5 have been developed that allow the production of multigram quantities without the need of any chromatographic purification. Broad and selective elaboration of the heteroaromatic scaffolds has also been accomplished.

IMIDAZO-PYRIDAZINONE DERIVATIVES AND IMIDAZO-PYRIDONE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS

The invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula (I), wherein Y and R1 to R4 are defined as indicated in claim 1, the tautomers, enantiomers, diastereomers, mixtures, and salts thereof that have valuable pharmacological properties, especially an inhibiting effect on the activity of the dipeptidyl peptidase IV (DPP-IV) enzyme.