81374-84-7

Basic information

• Product Name: Hydroxy-phenyl-thioacetic acid S-(2-morpholin-4-yl-ethyl) ester
• CAS NO: 81374-84-7
• Molecular Weight: 281.376
• Mol File: 81374-84-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Hydroxy-phenyl-thioacetic acid S-(2-morpholin-4-yl-ethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Hydroxy-phenyl-thioacetic acid S-(2-morpholin-4-yl-ethyl) ester(81374-84-7)
• EPA Substance Registry System: Hydroxy-phenyl-thioacetic acid S-(2-morpholin-4-yl-ethyl) ester(81374-84-7)

Safety Data

• Hazardous Substances Data: 81374-84-7(Hazardous Substances Data)

Upstream product

• 4542-46-5 2-(morpholin-4-yl)ethanethiol 
• 51034-71-0 <1-2H>phenylglyoxal 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 

Relevant articles and documents

Reaction of Thiols with Phenylgyoxal To Give Thiolesters of Mandelic Acid. 2. Intramolecular Genaral-Base Catalysis and Change in Rate-Determinimg Step

Reactions of phenylglyoxal (1) with N-(2-mercaptoethyl)morpholine (2a) and -piperidine (2b) to give the thiolesters (4) of mandelic acid have been kinetically investigated at 30 deg C.The reaction proceeds through the initial formation of a hemithioacetal (3) (rapid equilibration with the equilibrium constant Kh = 400-1500 M-1) and its rearrangement via the intramolecular general-base-catalyzed proton transfers to form 4.The pH-rate profile and primary kinetic isotope effects showed that the deprotonation to form an enediol intermediate (5) is rate determining in the reaction with 2a.In the case of 2b, a change in the rate-determining step was observed.At pH 2+, Mg2+, and Ca2+ in aqueous solutions even at low ionic strength.