814-80-2 Usage
Description
Calcium lactate is a black or white crystalline salt made by the action of lactic acid on calcium carbonate. It is used in foods (as an ingredient in baking powder) and given medicinally. Its E number is E327. It is created by the reaction of lactic acid with calcium carbonate or calcium hydroxide. Calcium lactate is often found in aged cheeses. Small crystals of it precipitate out when lactic acid is converted into a less soluble form by the bacteria active during the ripening process. In medicine, calcium lactate is most commonly used as an antacid and also to treat calcium deficiencies. Calcium lactate can be absorbed at various pHs and does not need to be taken with food for absorption for these reasons. Calcium lactate is added to sugar-free foods to prevent tooth decay. When added to chewing gum containing xylitol, it increases the remineralization of tooth enamel.It is also added to fresh-cut fruits such as cantaloupes to keep them firm and extend their shelf life, without the bitter taste caused by calcium chloride, which can also be used for this purpose.
Chemical Properties
Calcium lactate occurs as white or almost white, crystalline or
granular powder. It is slightly efflorescent.
Uses
Different sources of media describe the Uses of 814-80-2 differently. You can refer to the following data:
1. Calcium Lactate is the calcium salt of lactic acid which is soluble in
water. it has a solubility of 3.4 g/100 g of water at 20°c and is very
soluble in hot water. it is available as a monohydrate, trihydrate,
and pentahydrate. the trihydrate and pentahydrate have solubili-
ties of 9 g in 100 ml of water at 25°c. it contains approximately 14%
calcium. it is used to stabilize and improve the texture of canned
fruits and vegetables by converting the labile pectin to the less solu-
ble calcium pectate. it thereby prevents structural collapse during
cooking. it is used in angel food cake, whipped toppings, and
meringues to increase protein extensibility which results in an
increase of foam volume. it is also used in calcium fortified foods
such as infant foods and is used to improve the properties of dry
milk powder.
2. As a preservative in foods and beverages; in dentifrices.
3. Lactic Acid Calcium Salt is used in foods as an ingredient in baking powder. Lactic Acid Calcium Salt is also used as an antacid and also to treat calcium deficiencies.
Production Methods
Calcium lactate is prepared commercially by neutralization with
calcium carbonate or calcium hydroxide of lactic acid obtained
from fermentation of dextrose, molasses, starch, sugar, or whey.
Hazard
A poison.
Pharmaceutical Applications
Calcium lactate is used as a bioavailability enhancer and nutrient
supplement in pharmaceutical formulations.
A spray-dried grade of calcium lactate pentahydrate has been
used as a tablet diluent in direct compression systems, and has
been shown to have good compactability. The properties of the
pentahydrate form have been considered superior to those of
calcium lactate trihydrate when used in direct compression tablet
formulations. Tablet properties may be affected by the hydration
state of the calcium lactate and particle size of the material: reducing
particle size increased crushing strength, whereas storage of tablets
at elevated temperature resulted in dehydration accompanied by a
reduction in crushing strength.
Calcium lactate has also been used as the source of calcium ions
in the preparation of calcium alginate microspheres for controlled-
release delivery of active agents. It has been shown to result in lower
calcium concentrations in the finished microspheres when compared
with calcium acetate.
Therapeutically, calcium lactate has been used in preparations
for the treatment of calcium deficiency.
Safety
Calcium lactate was found to have no toxic or carcinogenic effects
when dosed at levels of 0%, 2.5%, and 5% in drinking water to
male and female rats for 2 years.
storage
Calcium lactate can exist in a number of hydration states, which are
characterized as anhydrous, monohydrate, trihydrate, and pentahydrate.
Dehydration of the pentahydrate form is rapid at
temperatures of 558℃ and above. Dehydration is reported to be
accompanied by some loss of crystallinity. Tablet crushing
strength was reported to be reduced following dehydration of
calcium lactate pentahydrate.
Purification Methods
Crystallise it from warm water (10mL/g) by cooling to 0o. [Beilstein 3 IV 636.]
Incompatibilities
Calcium salts, including the lactate, can display physical incompatibility
with phosphate in the diet or therapeutic preparations, for
example in enteral feed mixtures.
Regulatory Status
GRAS listed except for infant foods/formulas. Accepted as a
food additive in Europe. Calcium lactate (anhydrous) is included in
the FDA Inactive Ingredients Database (vaginal, tablet). It is used in
oral dosage forms. Included in vaginal pessary formulations
licensed in the UK.
Check Digit Verification of cas no
The CAS Registry Mumber 814-80-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,1 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 814-80:
(5*8)+(4*1)+(3*4)+(2*8)+(1*0)=72
72 % 10 = 2
So 814-80-2 is a valid CAS Registry Number.
InChI:InChI=1/2C3H6O3.Ca/c2*1-2(4)3(5)6;/h2*2,4H,1H3,(H,5,6);/q;;+2/p-2
814-80-2Relevant articles and documents
Synthesis of calcium phosphate powder from calcium lactate and ammonium hydrogen phosphate for the fabrication of bioceramics
Safronova,Putlyaev,Andreev,Filippov, Ya. Yu.,Knotko,Shatalova,Evdokimov
, p. 859 - 868 (2017)
A calcium phosphate powder has been synthesized from aqueous 0.25, 0.5, and 1.0 M calcium lactate and ammonium hydrogen phosphate solutions atat a Ca/P = 1, without pH adjusting. According to X-ray diffraction data, the as-synthesized powder consisted of brushite (CaHPO4 · 2H2O) and octacalcium phosphate (Ca8(HPO4)2(PO4)4 · 5H2O). After heat treatment in the range 500–700°C, the powders were gray in color because of the destruction of the reaction by-product. The powders heat-treated in the range 500–700°C consisted largely of γ-Ca2P2O7. The ceramics prepared from the synthesized powders by firing at 1100°C consisted of β-Ca2P2O7 and β-Ca3(PO4)2.
PREPARATION METHOD OF THE HIGH ACTIVATED CALCIUM BY SONOCHEMISTRY
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Paragraph 0073-0078; 0080-0081, (2019/10/29)
An objective of the present invention is to provide a method for manufacturing an organic acid calcium salt (calcium citrate, calcium lactate) having a high degree of ionization and easy to be solved in water. To achieve this, the method comprises the steps of: performing pretreatment by mixing one or more kinds selected from a group consisting of calcium carbonate and calcium oxide with solvent, and irradiating ultrasonic waves to the solution; a step of mixing an organic acid with the solution to form a mixture; and a step of irradiating ultrasonic waves to the mixture formed by mixing the organic acid. Accordingly, provided is an effect of providing an organic calcium salt having a high degree of ionization and capable of being solved by several or more times solubility of each compound. Moreover, the method for manufacturing an organic acid calcium salt has a simple process and equipment and an excellent effect of being manufactured within 10 minutes.COPYRIGHT KIPO 2019
Tandem catalytic conversion of glycerol using solid catalysts followed by transesterification to produce alkyl lactate
Ren, Shoujie,Ye, X. Philip,Ayers, Paul D.
, p. 53230 - 53239 (2015/06/30)
This study investigated alkyl lactate production from glycerol by tandem processes which included glycerol conversion to calcium lactate using solid catalysts and subsequent transesterification of calcium lactate to alkyl lactate using methanol/ethanol and carbon dioxide. The effect of reaction conditions on alkyl lactate production was systematically investigated. A central composite design (CCD) and response surface methodology were used to design the experiments and evaluate the optimum process conditions. At the optimum conditions, the methyl lactate yield reached 57 mol% with a glycerol conversion of 94 mol% using refined glycerol. A yield of approximately 42 mol% for ethyl lactate was obtained using refined glycerol at the optimum conditions. Similar glycerol conversion and alkyl lactate yields were obtained using crude glycerol, indicating that the impurities in the crude glycerol had no significant effects on alkyl lactate production. The examination of regenerated catalysts that had been reused twice showed no negative effects on glycerol conversion and methyl lactate production. Compared to the traditional lactic acid and alkyl lactate production, this two-step process for alkyl lactate production from glycerol is both economical and environmentally benign since no gypsum was produced and the solid catalysts can be regenerated and reused.
