81479-48-3

Basic information

• Product Name: (5-tert-butyl-isoxazol-3-yl)-carbaMic acid phenyl ester, (5-tert-butylisoxazol-3-yl)carbaMic acid phenyl ester
• Synonyms: (5-tert-butyl-isoxazol-3-yl)-carbaMic acid phenyl ester, (5-tert-butylisoxazol-3-yl)carbaMic acid phenyl ester;phenyl (5-(tert-butyl)isoxazol-3-yl)carbamate;Carbamic acid,N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-, phenyl ester;Phenyl N-(5-tert-butyl-1,2-oxazol-3-yl)carbamate
• CAS NO: 81479-48-3
• Molecular Formula: C₁₄H₁₆N₂O₃
• Molecular Weight: 260.28844
• Mol File: 81479-48-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 362.9±34.0 °C(Predicted)
• Appearance: /
• Density: 1.198±0.06 g/cm3(Predicted)
• PKA: 11.38±0.70(Predicted)
• CAS DataBase Reference: (5-tert-butyl-isoxazol-3-yl)-carbaMic acid phenyl ester, (5-tert-butylisoxazol-3-yl)carbaMic acid phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (5-tert-butyl-isoxazol-3-yl)-carbaMic acid phenyl ester, (5-tert-butylisoxazol-3-yl)carbaMic acid phenyl ester(81479-48-3)
• EPA Substance Registry System: (5-tert-butyl-isoxazol-3-yl)-carbaMic acid phenyl ester, (5-tert-butylisoxazol-3-yl)carbaMic acid phenyl ester(81479-48-3)

Safety Data

• Hazardous Substances Data: 81479-48-3(Hazardous Substances Data)

Usage

General Description

"(5-tert-butyl-isoxazol-3-yl)-carbaMic acid phenyl ester and (5-tert-butylisoxazol-3-yl)carbaMic acid phenyl ester are both organic compounds commonly used in pharmaceutical research and development. These chemicals have potential applications in the synthesis of various pharmaceutical drugs and are also used as building blocks in organic chemistry. They are known for their beneficial pharmacological properties and are often studied for their potential therapeutic effects. Additionally, these compounds are also used as research tools in the study of biological pathways and drug interactions. Overall, these chemicals play an important role in the field of medicinal chemistry and drug discovery."

Upstream product

• 55809-36-4 3-amino-5-tert-butylisoxazole 
• 1885-14-9 phenyl chloroformate 

Relevant articles and documents

NEW THERAPEUTIC AGENTS FOR THE TREATMENT OF HAEMATOLOGICAL PATHOLOGIES

The present invention relates to compounds having a tetracyclic system and the use thereof as new therapeutic agents in the treatment of acute myeloid leukemia (AML), preferably in FLT3/ITD hemizygote patients resistant to conventional therapies. The invention also relates to 5,7-dihydro-4H-[1,3]thiazolo[4,5-e]isoindol-2-amine compounds useful as intermediates for the synthesis of tetracyclic imidazo[2',1':2,3][1,3]thiazolo[4,5-e]isoindole compounds.

Synthesis and biological evaluation of novel 5,6-dihydrobenzo[h]quinazoline derivatives as FLT3 inhibitors

Fms-like tyrosine kinase 3 (FLT3) is widely expressed and often mutated in acute myeloid leukemia (AML), which makes it an important target for the treatment of AML. The structure-based synthesis and biological evaluation of 5,6-dihydrobenzo[h]quinazoline

Benzo imidazo [2, 1-b] thiazole compound and application thereof (by machine translation)

The invention discloses a benzoimidazo [2, 1-b] thiazole compound and application thereof, and belongs to the technical field of medicines. The inhibitory activity of the synthesized benzimidazo [2, 1-b] thiazole analogues on FLTT3 is more than 90%, wherein the compounds (compounds 2 , 4, 6, 8 and 10) are IC of FLTT3-ITD kinase. 50 Lower value, in particular compound 2, IC IC50 The value is only 5.60 nm, and therefore the compound of the present invention may be used as an inhibitor FLTT3, or for preparing a drug capable of modulating or suppressing diseases associated with abnormal cell proliferation by affecting the enzymatic activity of one or more tyrosine kinases and interfering with aberrant cell proliferation, having a wide application prospect. (by machine translation)