81547-72-0

Basic information

• Product Name: 2-BROMO-1-(2,6-DICHLOROPHENYL)ETHANONE
• Synonyms: 2-BROMO-1-(2,6-DICHLOROPHENYL)ETHANONE;2-Bromo-2',6'-dichloroacetophenone;Ethanone, 2-broMo-1-(2,6-dichlorophenyl)-
• CAS NO: 81547-72-0
• Molecular Formula: C₈H₅BrCl₂O
• Molecular Weight: 267.93
• Mol File: 81547-72-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 259 ºC
• Flash Point: 110 ºC
• Appearance: /
• Density: 1.695
• Refractive Index: 1.5795
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-BROMO-1-(2,6-DICHLOROPHENYL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(2,6-DICHLOROPHENYL)ETHANONE(81547-72-0)
• EPA Substance Registry System: 2-BROMO-1-(2,6-DICHLOROPHENYL)ETHANONE(81547-72-0)

Safety Data

• Hazardous Substances Data: 81547-72-0(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-(2,6-dichlorophenyl)ethanone is a chemical compound that is often used as an intermediate in the synthesis of other organic compounds. It is a pale yellow liquid with a strong odor, and is typically handled and stored under strict safety measures due to its toxic and irritant properties. 2-BROMO-1-(2,6-DICHLOROPHENYL)ETHANONE is commonly used in the pharmaceutical and agrochemical industries for the production of various drugs, pesticides, and herbicides. It is also used in research and development laboratories as a reagent for organic synthesis and in the manufacturing of specialty chemicals. Additionally, 2-Bromo-1-(2,6-dichlorophenyl)ethanone has potential applications in the field of materials science and in the development of new chemical technologies.

Upstream product

• 2040-05-3 2,6 dichloroacetophenone 
• 1194-65-6 2,6-dichloro-benzonitrile 

Downstream Products

• 27523-07-5 1-(2,6-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol 
• 1454838-72-2 4-(5-(2,6-dichlorophenyl)-1H-imidazol-2-yl)pyridine 
• 1361412-98-7 N-{5-[(2,6-dichlorophenyl)carbonyl]-4-phenyl-1,3-thiazol-2-yl}-2-[4-(ethylsulfonyl)phenyl]acetamide 
• 1361413-54-8 (2-amino-4-phenyl-1,3-thiazol-5-yl)(2,6-dichlorophenyl)methanone 
• 90553-63-2 4-(2,6-Dichloro-phenyl)-2,6-dimethyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine 
• 90553-34-7 1-(2,6-Dichloro-phenyl)-2-[methyl-(5-methyl-thiophen-2-ylmethyl)-amino]-ethanol 
• 78389-12-5 2-Chloracetylamino-3-(2,6-dichlorbenzoyl)-thiophen 
• 78389-13-6 3-(2,6-Dichlorbenzoyl)-2-jodacetylamino-thiophen 
• 78389-10-3 2-Amino-3-(2,6-dichlorbenzoyl)-thiophen 
• 71463-50-8 3-(2',6'-dichlorophenyl)-3-oxopropionitrile 
• 81547-74-2 [2-(2,6-Dichloro-phenyl)-2-oxo-ethyl]-phosphonic acid diethyl ester 

Relevant articles and documents

Microwave-assisted synthesis and luminescent activity of imidazo[1,2-a]pyridine derivatives

In this work, a series of phenacyl bromide derivatives was synthesized and employed as key intermediate for the synthesis of substituted imidazo[1,2-a]pyridines. First, phenacyl bromide molecules were obtained from the bromination reaction of acetophenones assisted by microwave irradiation, obtaining the products 4a-v in a 15 minutes reaction with yields in the range of 50% to 99%. Subsequently, the conjugation of these molecules with 2-aminopyridine conduced to the production of imidazo[1,2-a]pyridine derivatives (7a-v) in a 60-second reaction with yields of 24% to 99%. Improved yields were determined with respect to those obtained with more tedious methodologies like thermally and mechanically assisted routes. Intense luminescence emissions in the purple and blue regions of the electromagnetic spectra were observed under UV excitation according to the nature of the substituents. This environmentally friendly methodology is expected to constitute an important class of organic compounds for the development of biomarkers, photochemical sensors, and medicinal applications.

NOVEL COMPOUNDS

Disclosed are retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

Process for producing optically active carbinols

The present invention relates to a process for producing optically active halomethyl phenyl carbinols of the formula (1), comprising reducing halomethyl phenyl ketones of the formula (2) using an asymmetric reducing agent obtained from boranes and optically active α-phenyl-substituted-β-amino alcohols of the formula (3) or optically active α-non-substituted-β-amino alcohols of the formula (4). The present invention further relates to a process for producing optically active carbinols, comprising reacting a prochiral keytone with an asymmetric reducing agent obtained from optically active β-amino alcohols of the formula (5), a metal boron hydride and Lewis acid or lower dialkyl sulfuric acid. All of the formulas (1) to (5) are the same as shown in the specification.