815586-77-7

Basic information

• Product Name: 1H-Indole-3-carbonitrile,2-methyl-5-nitro-(9CI)
• Synonyms: 1H-Indole-3-carbonitrile,2-methyl-5-nitro-(9CI)
• CAS NO: 815586-77-7
• Molecular Formula: C10H7N3O2
• Molecular Weight: 201.18148
• Product Categories: METHYL
• Mol File: 815586-77-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Indole-3-carbonitrile,2-methyl-5-nitro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-3-carbonitrile,2-methyl-5-nitro-(9CI)(815586-77-7)
• EPA Substance Registry System: 1H-Indole-3-carbonitrile,2-methyl-5-nitro-(9CI)(815586-77-7)

Safety Data

• Hazardous Substances Data: 815586-77-7(Hazardous Substances Data)

Usage

General Description

1H-Indole-3-carbonitrile, 2-methyl-5-nitro-(9CI) is a chemical compound with the molecular formula C11H8N2O2. It is a derivative of indole, containing a cyano and a nitro group in the 3 and 2 positions, respectively. 1H-Indole-3-carbonitrile,2-methyl-5-nitro-(9CI) is commonly used in the synthesis of pharmaceuticals, agrochemicals, and dyes, as it has diverse biological and pharmacological activities. It is also known for its potential use in the development of anti-cancer and anti-inflammatory drugs. Additionally, it has been studied for its antimicrobial and antioxidant properties. Overall, 1H-Indole-3-carbonitrile, 2-methyl-5-nitro-(9CI) is a versatile compound with a wide range of potential applications in various fields.

Upstream product

• 3558-17-6 2-Methyl-5-nitro-1H-indole-3-carboxaldehyde 
• 7570-47-0 5-nitro-2-methylindole 

Relevant articles and documents

Copper-catalyzed synthesis and anticancer activity evaluation of indolo[1,2-a]quinoline derivatives

A simple and effective one-pot synthesis of substituted indolo[1,2-a]quinolines has been developed. The desired products were obtained in up to 98% yield when substituted 2-methyindoles were treated with 2-iodobenzaldehyde in the presence of Cs2CO3, CuI and L-proline. Our mechanistic study confirmed that the reaction sequence involved an intermolecular Knoevenagel reaction followed by an intramolecular Ullmann-type coupling reaction. Moreover, some of the synthesized compounds were found to be active against human breast (MCF-7) and colorectal (HCT-116) cancer cells with IC50 values of 27.96 μM and in the range of 6.21–46.91 μM, respectively.

Pd(OAc)2-catalyzed C-H activation of indoles: a facile synthesis of 3-cyanoindoles

Indoles undergo smooth cyanation with CuCN in the presence of 20 mol % Pd(OAc)2 and 40 mol % CuBr2 in DMF to produce a wide range of the corresponding 3-cyanoindoles in good yields with high regioselectivity.

COMPOUNDS USEFUL AS PROMOTERS OF SMN2

The present invention relates to compounds useful as promoters of the SMN2 gene. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of Spinal Muscular Atrophy.